September 2023
Volume 23, Issue 11
Open Access
Optica Fall Vision Meeting Abstract  |   September 2023
Poster Session: Laminar and cell class distinctions for pre-saccadic attention in marmoset MT/MTC
Author Affiliations
  • Amy Bucklaew
    University of Rochester
  • Shanna Coop
    Stanford University
  • Gabriel Sarch
    Carnegie Mellon Univeristy
  • Jude Mitchell
    University of Rochester
Journal of Vision September 2023, Vol.23, 39. doi:
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      Amy Bucklaew, Shanna Coop, Gabriel Sarch, Jude Mitchell; Poster Session: Laminar and cell class distinctions for pre-saccadic attention in marmoset MT/MTC. Journal of Vision 2023;23(11):39.

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      © ARVO (1962-2015); The Authors (2016-present)

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Pre-saccadic attention has been related to enhanced neural responses before saccades made into a neuron’s receptive field in macaque visual cortex (Moore and Chang 2009). However, much remains unknown about the underlying circuit mechanisms. Using the marmoset, a small New World monkey with a smooth brain, we examined laminar and cell class distinctions during pre-saccadic attention in motion selective areas MT/MTC. In a saccade foraging task, marmosets made a saccade from a central fixation point to one of three equally eccentric random dot field stimuli. We positioned the stimuli such that one foraged location overlapped the receptive fields of neurons under study and examined how tuning functions for motion direction changed. Tuning curves were fit with an adjusted Von Mises curve that estimates baseline, gain, and tuning width. We found in two animals that neurons on average exhibited increases in baseline and gain with pre-saccadic attention, but no changes in tuning width. In a single animal we were able to dissect the population by cell class and layer. We found that increases in gain were predominantly among broad spiking neurons in superficial layers whereas additive increases in rate were shared across layers and cell types. This suggests that superficial layer broad spiking neurons, the putative projection neurons that would relay information to downstream cortical areas, have a privileged role for encoding enhanced motion sensitivity during pre-saccadic attention.

 Funding: Funding: SC, AB, and JFM from NIH EY030998; GS from NSF GRF 2020305476

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