Abstract
Since the discovery of orientation-selective neurons in the cat primary visual cortex (V1), how the mammalian nervous system computes the orientation of visual stimuli has been a flagship question in neuroscience. With the recent advances in in vivo imaging of neural activity using genetically encoded indicators and two-photon fluorescence microscopy, we can now achieve synapse-resolving functional imaging and kilohertz imaging of membrane voltage in the mouse V1. I will describe our recent advancements in imaging visual processing at high spatiotemporal resolution, as well as two studies on the orientation selectivity of neurons in the mouse visual pathway.