September 2024
Volume 24, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2024
Oblique eccentric gaze holding evokes larger horizontal than vertical rebound nystagmus
Author Affiliations & Notes
  • Terence L. Tyson
    University of California, Berkeley
    NASA Ames Research Center
  • Jorge Otero-Millan
    University of California, Berkeley
    Johns Hopkins University
  • Footnotes
    Acknowledgements  This work was supported by the NASA Ames Research Center Graduate Fellowship Program.
Journal of Vision September 2024, Vol.24, 1331. doi:https://doi.org/10.1167/jov.24.10.1331
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      Terence L. Tyson, Jorge Otero-Millan; Oblique eccentric gaze holding evokes larger horizontal than vertical rebound nystagmus. Journal of Vision 2024;24(10):1331. https://doi.org/10.1167/jov.24.10.1331.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Rebound nystagmus (RN) has been used to probe the adaptation mechanisms of the gaze holding system. This type of nystagmus is invoked upon returning to central gaze after prolonged fixation at an eccentric point and it is thought to reflect a set-point adaptation of the neural integrator circuit. Previous studies have only observed horizontal RN after horizontal eccentric gaze holding, reflecting adaptation of the horizontal neural integrator. The current study seeks to elucidate how eccentric gaze at oblique target locations, where there are equal horizontal and vertical components, affects the characteristics of the resulting RN. For a given trial, subjects were instructed to fixate a central flashing target for 5 seconds, then fixate an eccentric continuous target for 30 seconds at one of six possible locations (4 oblique and 2 horizontal targets), and finally fixate centrally at a flashing target for 15 seconds where RN is assessed. Binocular eye-tracking data were collected at 250 Hz. Slow-phase velocity (SPV) or the slow drift part of the nystagmus was used to quantify the magnitude of RN. Subjects showed elevated SPV in the horizontal component (2.3 deg/s), but less in the vertical component (1.4 deg/s) after oblique eccentric gaze holding, reflecting an oblique RN. The smaller vertical RN may reflect a different behavior of the horizontal and vertical neural integrators which are anatomically separated. Under the current paradigm, oblique gaze holding would appear to have a smaller effect on adaptation of the vertical integrator than in the horizontal integrator. Further investigation is needed to establish the reference frame of this distinction between the horizontal and vertical integrator circuits.

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