September 2024
Volume 24, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2024
Effect of Cerebral Visual Impairment on Functional-Structural Coupling of the Attention Networks
Author Affiliations & Notes
  • Negin Nadvar
    The Lab of Neuroimaging and Vision Science, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
  • Marie Drottar
    The Lab of Neuroimaging and Vision Science, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
  • Claire Manley
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA
  • Peter Bex
    Department of Psychology, Northeastern University, Boston, MA
  • Lotfi Merabet
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA
  • Corinna Bauer
    The Lab of Neuroimaging and Vision Science, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA
  • Footnotes
    Acknowledgements  National Eye Institute
Journal of Vision September 2024, Vol.24, 1278. doi:https://doi.org/10.1167/jov.24.10.1278
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      Negin Nadvar, Marie Drottar, Claire Manley, Peter Bex, Lotfi Merabet, Corinna Bauer; Effect of Cerebral Visual Impairment on Functional-Structural Coupling of the Attention Networks. Journal of Vision 2024;24(10):1278. https://doi.org/10.1167/jov.24.10.1278.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Visual attentional processes, including selective attention, are often impaired in individuals with Cerebral Visual Impairment (CVI) [1]. Yet, the underlying neural correlates thereof remain unclear. This study investigated potential differences in the relationship between white matter integrity and resting state functional connectivity (rsFC) of the dorsal (DAN) and ventral (VAN) attention networks underlying visual attention [2] in individuals with CVI compared to controls. Resting-state fMRI, diffusion, and METRICS [3] data were collected on a 3T Philips scanner for 25 participants (16 control, 9 CVI). Average rsFC was calculated within the DAN and VAN, and also between the DAN, VAN, thalamus, and early visual regions. Tract volume, fractional anisotropy (FA), radial/axial diffusivity (RD/AD), and myelin water fraction (MWF) and intra-extracellular T2 (IET2) [4] were calculated for the superior longitudinal fasciculus (SLF) (divisions I, II, and III), inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF), and the anterior (ATR), superior (STR), and posterior (PTR) thalamocortical radiations. Spearman partial correlations within each group (adjusting for age) followed by FDR correction for multiple comparisons were used to investigate the functional-structural coupling of the attention networks. In the control group, within-network rsFC for the DAN was positively correlated with FA of the SLF I. Between-network connectivity of the DAN was significantly positively correlated with FA and negatively correlated with RD of the left ILF and FA of the bilateral IFOF. Between-network connectivity of the VAN was significantly positively correlated with FA of the left ILF and IFOF. Functional connectivity between the thalamus and VAN was significantly negatively associated with PTR IET2. No significant associations were observed in the CVI group. Overall, the results suggest that CVI may be associated with aberrant functional-structural coupling of the attention networks. The relationship with the previously observed selective attention deficits in individuals with CVI needs to be further investigated.

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