Journal of Vision Cover Image for Volume 25, Issue 5
April 2025
Volume 25, Issue 5
Open Access
Optica Fall Vision Meeting Abstract  |   April 2025
Poster Session: Assessing the relationship between the cone mosaic and AO-corrected visual acuity
Author Affiliations
  • Mina Gaffney
    Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, WI, United States
  • Joseph Kreis
    Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States
  • Heather Heitkotter
    Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States
  • Emma Warr
    Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, United States
  • Ashleigh Walesa
    Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, United States
  • Katherine Hemsworth
    Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, United States
  • Emily Kind
    School of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States
  • Pavan Tiruveedhula
    Herbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, CA, United States
  • Austin Roorda
    Herbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, CA, United States
  • William S. Tuten
    Herbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, CA, United States
  • Joseph Carroll
    Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, WI, United States
    Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States
    Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, United States
Journal of Vision April 2025, Vol.25, 20. doi:https://doi.org/10.1167/jov.25.5.20
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      Mina Gaffney, Joseph Kreis, Heather Heitkotter, Emma Warr, Ashleigh Walesa, Katherine Hemsworth, Emily Kind, Pavan Tiruveedhula, Austin Roorda, William S. Tuten, Joseph Carroll; Poster Session: Assessing the relationship between the cone mosaic and AO-corrected visual acuity. Journal of Vision 2025;25(5):20. https://doi.org/10.1167/jov.25.5.20.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Using adaptive optics (AO), it is possible to deliver near diffraction-limited stimuli to the human retina to assess the relationship between the cone mosaic and visual function. Here we sought to establish device-specific control data for future studies of individuals with retinal disease. We used AOSLO to quantify the cone mosaic and measure visual acuity in the dominant eye of 18 individuals (7M, 11F; 15-67 years) without retinal pathology. Average density at the cone density centroid was 186,925 cones/mm^2. Visual acuity was assessed using an AO-corrected Snellen E presented via a QUEST-driven four-alternative forced-choice task. The mean observed acuity across individuals was -0.23 (±0.08) logMAR. We compared observed acuity to that predicted by foveal cone spacing, using the average spacing within a given individual’s 95% bivariate contour ellipse area centered on an estimated preferred-retinal fixation locus. The mean (± SD) predicted acuity across individuals was -0.30 (±0.03) logMAR. The ratio of observed:predicted acuity ranged from 1.54 to 0.30 (average = 0.78). Six individuals had observed acuity equal to or better than that predicted by their foveal cone spacing, while the other 12 had an observed acuity worse than that predicted by their foveal cone spacing. These results warrant further examination of factors contributing to the variation of AO-based acuity measures, including experimental differences, internal response bias, and other biological factors.

Footnotes
 Funding: R01EY033580, R01EY017607, F31EY036692, F31EY033204, F31EY036709, T32EY014537, T35HL072483
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