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Cornea March 2025

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

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Boda Li; Junpeng Liu; Di Zhang; Yiran Chu; Zeying Chen; Jiaruei Tsao; Taige Chen; Jiaxuan Jiang; Kai Hu
TAGS: autophagy, dry eye syndromes, mice, mtor serine-threonine kinases, oxidative stress, western blotting, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):44. https://doi.org/10.1167/iovs.66.3.44

Includes: Supplemental Content

Cornea March 2025

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

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Zhao-Jing Lu; Jin-Guo Ye; Jing-Ni Li; Jiang-Bo Liang; Ming Zhou; Qiu-Ling Hu; Qi-Kai Zhang; Yu-Heng Lin; Ying-Feng Zheng
TAGS: corneal epithelium, genes, mice, wounds and injuries, chromatin, cornea, wound healing, multiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):9. https://doi.org/10.1167/iovs.66.3.9

Includes: Supplemental Content

Immunology and Microbiology February 2025

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

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Lude Moekotte; Joke H. de Boer; Sanne Hiddingh; Aafke de Ligt; Xuan-Thanh-An Nguyen; Carel B. Hoyng; Chris F. Inglehearn; Martin McKibbin; Tina M. Lamey; Jennifer A. Thompson; Fred K. Chen; Terri L. McLaren; Alaa AlTalbishi; Daan M. Panneman; Erica G. M. Boonen; Sandro Banfi; Béatrice Bocquet; Isabelle Meunier; Elfride De Baere; Robert Koenekoop; Monika Ołdak; Carlo Rivolta; Lisa Roberts; Raj Ramesar; Rasa Strupaitė-Šileikienė; Susanne Kohl; G. Jane Farrar; Marion van Vugt; Jessica van Setten; Susanne Roosing; L. Ingeborgh van den Born; Camiel J. F. Boon; Maria M. van Genderen; Jonas J. W. Kuiper
TAGS: complement system proteins, hereditary retinal dystrophy, plasma, proteins, genotype, proteome, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):55. https://doi.org/10.1167/iovs.66.2.55

Includes: Supplemental Content

Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

Does Leveraging the Human Ventral Visual Stream Improve Neural Network Robustness?

Zhenan Shao; Linjian Ma; Bo Li; Diane M. Beck

Journal of Vision. 2024; 24(10):277. https://doi.org/10.1167/jov.24.10.277

Biochemistry and Molecular Biology September 2024

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi L. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du
TAGS: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars, induced pluripotent stem cells, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):5. https://doi.org/10.1167/iovs.65.11.5

Includes: Supplemental Content

Genetics August 2024

Frequency and Genetic Spectrum of Inherited Retinal Dystrophies in a Large Dutch Pediatric Cohort: The RD5000 Consortium

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Pam A. T. Heutinck; L. Ingeborgh van den Born; Maikel Vermeer; Adriana I. Iglesias Gonzales; Carel B. Hoyng; Jan Willem R. Pott; Hester Y. Kroes; Mary J. van Schooneveld; Camiel J. F. Boon; Maria M. van Genderen; Astrid S. Plomp; Yvonne de Jong-Hesse; Michelle B. van Egmond-Ebbeling; Lies H. Hoefsloot; Arthur A. Bergen; Caroline C. W. Klaver; Magda A. Meester-Smoor; Alberta A. H. J. Thiadens; Virginie J. M. Verhoeven
TAGS: child, cohort studies, dutch, genetics, hereditary retinal dystrophy, pediatrics, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):40. https://doi.org/10.1167/iovs.65.10.40

Includes: Supplemental Content

Retina June 2024

Multicentric Longitudinal Prospective Study in a European Cohort of MYO7A Patients: Disease Course and Implications for Gene Therapy

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Francesco Testa; Ester Carreño; L. Ingeborgh van den Born; Paolo Melillo; Irene Perea-Romero; Valentina Di Iorio; Giulia Risca; Clemente Maria Iodice; Ronald J. E. Pennings; Marianthi Karali; Sandro Banfi; Alberto Auricchio; Stefania Galimberti; Carmen Ayuso; Francesca Simonelli
TAGS: cohort studies, disease progression, european continental ancestry group, gene therapy, prospective studies, usher syndrome, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):25. https://doi.org/10.1167/iovs.65.6.25

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

A novel AAV-based gene therapy for glaucoma

Ling Wu; Carola Maturana; Zuliang Yao; Wei Wang; Bo Liang; Laura Hong

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5130.

ARVO Annual Meeting Abstract June 2024

Simple method for isolation and selective cultivation of primary porcine retinal endothelial cells and pericytes

Anna Bøgh Lindholm; Toke Bek; Anne Louise Askou; Thomas Corydon

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):277.

ARVO Annual Meeting Abstract June 2024

A Phase II, Multi-Center, Blinded, Randomized, Parallel-Controlled Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% Povidone Iodine) Gel Forming Ophthalmic Solution Compared to Ofloxacin Eye Drops in the Treatment of Acute Bacterial Conjunctivitis.

francis s mah; ting wang; Bo Liang; Qi Zhu; SUSAN SONG; SEAN ZHAO; JUN GAO; Yingxiao HUA; Weiyun SHI

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2785.

ARVO Annual Meeting Abstract June 2024

Development of a Long-Lasting In-situ Gel-Forming Solution for the Treatment of Conjunctivitis

Jieyu Zhu; Bo Liang; Xi Li; Haizhou Peng; Haiyang Zhu; Yijun Pan; Gang Wei

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3639.

ARVO Annual Meeting Abstract June 2024

World's First CRISPR/RNA-Targeting Therapy (HG202) for Patients with Neovascular Age-Related Macular Degeneration

Alvin Luk; Dongjun Xing; Boshi Liu; Weiwei Liu; Shuaishuai Zhang; Yuhan Jiang; Xuan Yao; Linyu Shi; Hui Yang; Yiqun Yuan; Xiaorong Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4357.

ARVO Annual Meeting Abstract June 2024

Nonclinical Development of a Novel Therapeutic Ophthalmic Eyelid Wipe to Treat Dry Eye Disease

Bo Liang; Brian G Short; Wei Wang; Jieyu Zhu; Yijun Pan; Joshua Fon; Laura Hong; Zuliang Yao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5763.

ARVO Annual Meeting Abstract June 2024

RNA interference using miR-agshRNA effectors as a platform for anti-angiogenic combination gene therapy

Thomas Stax Jakobsen; Bjørn Kristensen Fabian-Jessing; Rikke Lentz Adsersen; Anna Bøgh Lindholm; Anne Kirstine Køllner Bjerre; Toke Bek; Lars Aagaard; Anne Louise Askou; Thomas Corydon

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5319.

ARVO Annual Meeting Abstract June 2024

Manufacture and release testing of CellThRPE1 for treatment of dry age-related macular degeneration

Laura Baqué Vidal; Heather Main; Hazel Reilly; Sarah Saietz; Christoffer von Halling Laier; Paschalis Efstathopoulos; Fabio Elefante; Linda Boye Jensen; Marie Kragh; Dorthe Bach Toft; J. Carlos Villaescusa; Michael Wagner Christiansen; Anders P Kvanta; Katrin Markland; Pontus Blomberg; Fredrik Lanner

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1558.

ARVO Annual Meeting Abstract June 2024

Microbial keratitis isolates and outcomes at two tertiary eye centers in Southeast Asia

George Michael Sosuan; Ruben Lim Bon Siong; Ma. Dominga Padilla

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4919.

ARVO Annual Meeting Abstract June 2024

A1 amacrine cells modulate the activity of several output pathways in the primate retina

Shane Lind Boniec; Fred Rieke; Michael Manookin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5368.

ARVO Annual Meeting Abstract June 2024

Comparison of protein biomarker profile in tears from eyes of healthy subjects and dry eye disease patients using novel Olink® Proteomics Technology

Mitalee Tamhane; Scott Gladstein; Vivian Zhao; Lisa Borbridge; Katherine S Held; Xin Huang; Jie Shen; Mayssa Attar

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6565.

ARVO Annual Meeting Abstract June 2024

Automated segmentation of cone photoreceptors in AO-FIO: a multi-center study

Danilo Andrade De Jesus; Sander Wooning; Manon Van Haute; Filip Van den Broeck; Danuta M Sampson; Pam Heutinck; Kubra Liman; L. Ingeborgh van den Born; Marine Durand; Nicolas Chateau; Caroline C W Klaver; Alberta Thiadens; Theo van Walsum; Luisa Sanchez Brea

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1419.

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Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Does Leveraging the Human Ventral Visual Stream Improve Neural Network Robustness?

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

Frequency and Genetic Spectrum of Inherited Retinal Dystrophies in a Large Dutch Pediatric Cohort: The RD5000 Consortium

Multicentric Longitudinal Prospective Study in a European Cohort of MYO7A Patients: Disease Course and Implications for Gene Therapy

A novel AAV-based gene therapy for glaucoma

Simple method for isolation and selective cultivation of primary porcine retinal endothelial cells and pericytes

A Phase II, Multi-Center, Blinded, Randomized, Parallel-Controlled Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% Povidone Iodine) Gel Forming Ophthalmic Solution Compared to Ofloxacin Eye Drops in the Treatment of Acute Bacterial Conjunctivitis.

Development of a Long-Lasting In-situ Gel-Forming Solution for the Treatment of Conjunctivitis

World's First CRISPR/RNA-Targeting Therapy (HG202) for Patients with Neovascular Age-Related Macular Degeneration

Nonclinical Development of a Novel Therapeutic Ophthalmic Eyelid Wipe to Treat Dry Eye Disease

RNA interference using miR-agshRNA effectors as a platform for anti-angiogenic combination gene therapy

Manufacture and release testing of CellThRPE1 for treatment of dry age-related macular degeneration

Microbial keratitis isolates and outcomes at two tertiary eye centers in Southeast Asia

A1 amacrine cells modulate the activity of several output pathways in the primate retina

Comparison of protein biomarker profile in tears from eyes of healthy subjects and dry eye disease patients using novel Olink® Proteomics Technology

Automated segmentation of cone photoreceptors in AO-FIO: a multi-center study

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