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Retina May 2025

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

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Chengming Chen; Yanyan Lan; Weiming Yan; Xiaohong Zhang; Tian Li; Jing Han
TAGS: age-related macular degeneration, metabolites, plasma, proteins, european continental ancestry group
Trans. Vis. Sci. Tech.. 2025; 14(5):8. https://doi.org/10.1167/tvst.14.5.8

Includes: Supplemental Content

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Refractive Intervention April 2025

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

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Hou-Ren Tsai; Jeng-Hung Wang; Cheng-Jen Chiu
TAGS: cornea, orthokeratology, prospective studies, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2025; 14(4):5. https://doi.org/10.1167/tvst.14.4.5

Includes: Supplemental Content

Immunology and Microbiology February 2025

The Signature of Serum Modified Nucleosides in Uveitis

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Haoze Zhou; Yiqiu Hu; Guangming Qin; Jinfeng Kong; Xiujuan Hong; Cheng Guo; Jian Zou; Lei Feng
TAGS: nucleosides, uveitis, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):68. https://doi.org/10.1167/iovs.66.2.68

Includes: Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2025

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

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Xin Liu; Ying Yuan; Yue Wu; Chengcheng Zhu; Yuying Liu; Bilian Ke
TAGS: actins, integrins, myopia, sclera, fibroblasts, extracellular matrix, caviidae
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):22. https://doi.org/10.1167/iovs.66.2.22

Includes: Supplemental Content

Anatomy and Pathology/Oncology February 2025

Hepatic Satellite Cell Activation and Alteration of Vitamin A Status Are Relevant to the Aggravation of Retinopathy by T2DM

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Min-Chun Chang; David Pei-Cheng Lin; Han-Hsin Chang
TAGS: diabetes mellitus, type 2, vitamin a, liver injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):7. https://doi.org/10.1167/iovs.66.2.7

Includes: Supplemental Content

Cornea February 2025

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

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Xiaojuan Hu; Jiayao Feng; Chengjie Pan; Zhenzhen Sun; Jiechen Liu; Shuang Xie; Decheng Xiao; Xiaoyin Ma; Qinxiang Zheng; Wei Chen
TAGS: dry eye syndromes, hmgb1 protein, lysosomes, borderline neoplasms, apoptosis, homeostasis, cell death, stress, date of last normal period, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):5. https://doi.org/10.1167/iovs.66.2.5

Cornea January 2025

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

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Yankai Wei; Mei Sun; Xinyu Zhang; Chengyuan Zhang; Chao Yang; Hong Nian; Bei Du; Ruihua Wei
TAGS: dry eye syndromes, mice, sjogren's syndrome, stat3 protein, th17 cells, langer-giedion syndrome, dendritic cells, t-lymphocytes, mice, inbred nod, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):35. https://doi.org/10.1167/iovs.66.1.35

Includes: Supplemental Content

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

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Yanjing Huang; Chengjie He; Qiuling Hu; Zhong Liu; Xingyi Li; Wuyou Gao; Xuanwei Liang; Rongxin Chen; Zhen Mao; Xianchai Lin
TAGS: basal cell carcinoma, eyelid, genes, infiltrative basal cell carcinoma, metabolites, neoplasms, metabolic disturbance, tumor microenvironment, up-regulation (physiology), spectrometry, mass, matrix-assisted laser desorption-ionization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):11. https://doi.org/10.1167/iovs.66.1.11

Includes: Supplemental Content

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Retina December 2024

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

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Farhan E. Hiya; Yuxuan Cheng; Mengxi Shen; Jianqing Li; Alessandro Berni; Sandy Wenting Zhou; Gissel Herrera; Robert C. O'Brien; Giovanni Gregori; Ruikang K. Wang; Philip J. Rosenfeld
TAGS: chief complaint, drusen, eye, perfusion, reliability, diagnostic imaging, coronary arteriosclerosis, masks, computer assisted diagnosis, computer-aided detection systems
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):5. https://doi.org/10.1167/iovs.65.14.5

Anatomy and Pathology/Oncology November 2024

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

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Lauren A. Dalvin; Cynthia M. Andrews-Pfannkoch; David R. Miley; Tara L. Hogenson; Samantha A. Erickson; Shivani Malpotra; Kjersten J. Anderson; Mohammed E. Omer; Luciana L. Almada; Cheng Zhang; Hu Li; Diva R. Salomao; Carol L. Shields; Sara E. Lally; Rachel M. Malsch; James A. Armitage; Heather L. Holmes; Michael F. Romero; Michael P. Fautsch; Svetomir N. Markovic; Martin E. Fernandez-Zapico
TAGS: intraocular melanoma, neoplasms, organoids, translational research, immunohistochemistry, bap1 gene, transplantation, heterologous, atac trial
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):60. https://doi.org/10.1167/iovs.65.13.60

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2024

Adult Myopia Progression

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Noel A. Brennan; Xu Cheng; Mark A. Bullimore
TAGS: adult, myopia, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):49. https://doi.org/10.1167/iovs.65.13.49

Includes: Supplemental Content

Retina November 2024

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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David A. Antonetti; Cheng-Mao Lin; Sumathi Shanmugam; Heather Hager; Manjing Cao; Xuwen Liu; Alyssa Dreffs; Adam Habash; Steven F. Abcouwer
TAGS: diabetes mellitus, wounds and injuries, mice, retina, photoreceptors, reperfusion injury, streptozocin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):46. https://doi.org/10.1167/iovs.65.13.46

Includes: Supplemental Content

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Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

The Signature of Serum Modified Nucleosides in Uveitis

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

Hepatic Satellite Cell Activation and Alteration of Vitamin A Status Are Relevant to the Aggravation of Retinopathy by T2DM

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

Adult Myopia Progression

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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