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Article May 2025

Exploring for gloss: Active exploration in visual material perception

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Lisa P. Y. Lin; Knut Drewing; Katja Doerschner
TAGS: judgment, palm of hand, perception, motion, cues
Journal of Vision. 2025; 25(6):2. https://doi.org/10.1167/jov.25.6.2

Includes: Supplemental Content

Retina April 2025

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

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Xingyu Xiao; Jianchun Zhao; Shiqun Lin; Yajie Yang; Wenhui Li; Yan Zhou; Xiao Zhang; Rongping Dai
TAGS: diabetes mellitus, nonproliferative diabetic retinopathy, retinal vessels, renal function, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):72. https://doi.org/10.1167/iovs.66.4.72

Retina April 2025

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

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Jie Xu; Yi Li; Xiangyu Li; Xuan Tan; Lihua Liu; Lining Cao; Hui Xu
TAGS: interleukin-6, retina, zebrafish, microglia, signal transduction, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):67. https://doi.org/10.1167/iovs.66.4.67

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Retina April 2025

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

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Ssu-Yu Pan; Chien-Hsiang Weng; Shang-Feng Tsai; Hui-Ju Lin; Jun-Fu Lin; Ching-Heng Lin; I-Jong Wang; Chien-Chih Chou
TAGS: age-related macular degeneration, diabetes mellitus, type 2, dipeptidyl-peptidase iv inhibitors, sodium-glucose transporter 2 inhibitors, diabetes mellitus, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):58. https://doi.org/10.1167/iovs.66.4.58

Includes: Supplemental Content

Retina April 2025

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

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Yi-Han Huang; Yu-Shu Huang; Chien-Yu Lin; Ying-Ju Lai; Chang-Hao Yang; Tzzy-Chang Ho; Yi-Ting Hsieh; Po-Ting Yeh; Tso-Ting Lai; Chao-Wen Lin; Chung-May Yang; Pei-Lung Chen; Ta-Ching Chen
TAGS: constriction procedure, disease progression, retinitis pigmentosa, taiwanese, x-linked inheritance, eye, phenotype, exons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):59. https://doi.org/10.1167/iovs.66.4.59

Includes: Supplemental Content

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Cornea & External Disease April 2025

A Novel Approach to Fabricate Early Keratoconus Phantom Models

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Hui Tong; Mingjue Wu; Jianqiang Han; Lin Li; Haixia Zhang
TAGS: cornea, keratoconus, phantoms, imaging, silicones
Trans. Vis. Sci. Tech.. 2025; 14(4):18. https://doi.org/10.1167/tvst.14.4.18

Glaucoma April 2025

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie
TAGS: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):48. https://doi.org/10.1167/iovs.66.4.48

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang
TAGS: mice, microglia, visual cortex, interneurons, neurons, small nuclear rna, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):45. https://doi.org/10.1167/iovs.66.4.45

Includes: Supplemental Content

Methods April 2025

Hierarchical Bayesian augmented Hebbian reweighting model of perceptual learning

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Zhong-Lin Lu; Shanglin Yang; Barbara Anne Dosher
TAGS: body weight, hebbian theory, learning, perceptual learning, tissue approximation, linear regression, weight (force), datasets
Journal of Vision. 2025; 25(4):9. https://doi.org/10.1167/jov.25.4.9

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Retina April 2025

Fecal Microbial Profiles and Short-Chain Fatty Acid/Bile Acid Metabolomics in Patients With Age-Related Macular Degeneration: A Pilot Study

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Zaid Parekh; Jason Xiao; Amir Mani; Quadis Evans; Christopher Phung; Hugo A. Barba; Bingqing Xie; Ashley M. Sidebottom; Anitha Sundararajan; Huaiying Lin; Ramanujam Ramaswamy; David Dao; Reem Gonnah; Madeleine Yehia; Seenu M. Hariprasad; Mark D'Souza; Dinanath Sulakhe; Eugene B. Chang; Dimitra Skondra
TAGS: age-related macular degeneration, bile acids, feces, metabolites, metabolomics, pilot projects, volatile fatty acids, cohort studies, microbiome, gastrointestinal microbiome
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):21. https://doi.org/10.1167/iovs.66.4.21

Includes: Supplemental Content

Letters to the Editor April 2025

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

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James Lin; Ting-Wan Kao
TAGS: artificial intelligence, biological markers, diabetic nephropathy, perfusion, screening
Trans. Vis. Sci. Tech.. 2025; 14(4):11. https://doi.org/10.1167/tvst.14.4.11

Letters to the Editor April 2025

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

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Qinling Jiang; Lin Mou
TAGS: amino acids, branched-chain, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2025; 14(4):10. https://doi.org/10.1167/tvst.14.4.10

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Glaucoma April 2025

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

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Samantha Sze-Yee Lee; Gareth Lingham; Alex W. Hewitt; David A. Mackey
TAGS: intraocular pressure, retinal nerve fiber layer, young adult, eye, ophthalmic examination and evaluation
Trans. Vis. Sci. Tech.. 2025; 14(4):3. https://doi.org/10.1167/tvst.14.4.3

Includes: Supplemental Content

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Exploring for gloss: Active exploration in visual material perception

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

A Novel Approach to Fabricate Early Keratoconus Phantom Models

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

Hierarchical Bayesian augmented Hebbian reweighting model of perceptual learning

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Fecal Microbial Profiles and Short-Chain Fatty Acid/Bile Acid Metabolomics in Patients With Age-Related Macular Degeneration: A Pilot Study

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

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