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ARVO Annual Meeting Abstract June 2025

Phase 1/2 Gene Therapy Trial for Bietti Crystalline Corneoretinal Dystrophy

Liping Yang; Dongjun Xing; JINLU ZHANG; Boshi Liu; Shaohong Chen; Wang Li; Baoyuan Qu; Jing Qiao; Xiaoshuang Jiang; Haicun Jia; Xianjun Hu; Xuefeng Feng; Shicheng Yu; Ruixuan Jia; Hongliang Dou; Fang Lu; Xiaorong Li

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):6389.

ARVO Annual Meeting Abstract June 2025

Multi-Scale Transformer to Segment Retinal Layers with Shadow Breaks

Shaohua Pi; Razieh Ganjee; Bingjie Wang; Lingyun Wang; Chengcheng Zhao; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):569.

ARVO Annual Meeting Abstract June 2025

Characterizing birefringence features of retinal tissue with polarized light-based imaging

Zhangting Wang; Taranjit Singh; Owen Lailey; Mukhit Kulmaganbetov; Dusan Sarenac; Iman Salehi; Liuhe Wang; Davis Garrad; Connor Kapahi; Andrew Ernest Silva; Jelena Mirkovic; Benjamin Thompson; Dmitry Pushin

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1954.

ARVO Annual Meeting Abstract June 2025

Long-Term Efficacy and Safety of Repeated Low-Level Red Light Therapy for Myopia Control: A Real-World Study

Lili Wang; Yanpin Chen; Feng Jiang; Yang Xiao; Junwen Zeng

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5196.

ARVO Annual Meeting Abstract June 2025

Ixoberogene Soroparvovec (Ixo-vec) Intravitreal Gene Therapy for Neovascular AMD: 4-Year Safety and Efficacy Results from the OPTIC Trial

James Major; Charles Clifton Wykoff; David S Boyer; Carl Danzig; Carl D. Regillo; Brandon G. Busbee; Dante Joseph Pieramici; Brian C Joondeph; Arshad M. Khanani; Dina Akasheh; Joanna Do; Jennifer Danesh; Traci Clemons; Lixin Wang; Adam Turpcu; Rabia Ozden; Star Seyedkazemi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):6390.

ARVO Annual Meeting Abstract June 2025

Transformer-Based Method for Visualization and Quantification of 3-D Human Retinal Circulation from Single Volume in Commercial OCT

Lingyun Wang; Bingjie Wang; Jay Chhablani; Jose Alain Sahel; Shaohua Pi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):6298.

ARVO Annual Meeting Abstract June 2025

Detection of Double Layer Sign in OCT using a 3D foundation model

Yuka Kihara; Mengxi Shen; Yingying Shi; Liang Wang; Rita Laiginhas; Xiaoshuang Jiang; Alessandro Berni; Jeremy Liu; Farhan Hiya; Jianqing Li; Zixuan Liu; Sheng Wang; Giovanni Gregori; Philip J Rosenfeld; Aaron Y Lee

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1737.

ARVO Annual Meeting Abstract June 2025

In Situ Hybridization Demonstrates Ocular Distribution of Ixo-vec IVT Gene Therapy in Human Cadaver Eyes with wAMD and Supports Durable Clinical Efficacy

Julio Delano Nieves; Jenny Vo; Ruslan Grishanin; Marjan Behzadirad; Lixin Wang; Star Seyedkazemi; Brian C Joondeph; Romu Corbau

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4141.

Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

PDF

An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

PDF

Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Retina January 2025

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

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Guocheng Xiao; Mei Ge; Guoqing Qiao; Shuyu Liu; Na Li; Feng Liu; Yanye Lu; Qiushi Ren; Liqiang Wang
TAGS: adult, myopia, oxygen
Trans. Vis. Sci. Tech.. 2025; 14(1):18. https://doi.org/10.1167/tvst.14.1.18

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

PDF

Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Cornea October 2024

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

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Liqiong Zhu; Chaoqun Chen; Siqi Wu; Huizhen Guo; Lingyu Li; Li Wang; Dongmei Liu; Yu Zhan; Xinyue Du; Jiafeng Liu; Jieying Tan; Ying Huang; Kunlun Mo; Xihong Lan; Hong Ouyang; Jin Yuan; Xiangjun Chen; Jianping Ji
TAGS: cornea, homeostasis, pax6 transcription factor, scirrhous adenocarcinoma, epithelium, chronic exertional compartment syndrome, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):40. https://doi.org/10.1167/iovs.65.12.40

Includes: Supplemental Content

Cornea September 2024

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng
TAGS: cornea, corneal epithelium, genes, macaca fascicularis, wound healing, epithelium, transcription, genetic, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):43. https://doi.org/10.1167/iovs.65.11.43

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract July 2024

Fully Automated OCT-based Tissue Screening System

Shaohua Pi; Razieh Ganjee; Lingyun Wang; Riley Arbuckle; Chengcheng Zhao; Jose A. Sahel; Bingjie Wang; Yuanyuan Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PB0018.

ARVO Imaging in the Eye Conference Abstract July 2024

Reveal retinal ultra-structure with self-supervised denoising in vis-OCT

Lingyun Wang; Jose A. Sahel; Shaohua Pi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PP009.

Glaucoma July 2024

Differences in Systemic Pulse Waveform Between Individuals With Glaucoma, Glaucoma Suspects, and Healthy Controls

PDF

Hongli Yang; Grant Cull; Mingrui Yang; Lin Wang; Brad Fortune; Stuart K. Gardiner
TAGS: glaucoma, pulse waveform, waveforms, global longitudinal strain, blood pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):20. https://doi.org/10.1167/iovs.65.8.20

Includes: Supplemental Content

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Phase 1/2 Gene Therapy Trial for Bietti Crystalline Corneoretinal Dystrophy

Multi-Scale Transformer to Segment Retinal Layers with Shadow Breaks

Characterizing birefringence features of retinal tissue with polarized light-based imaging

Long-Term Efficacy and Safety of Repeated Low-Level Red Light Therapy for Myopia Control: A Real-World Study

Ixoberogene Soroparvovec (Ixo-vec) Intravitreal Gene Therapy for Neovascular AMD: 4-Year Safety and Efficacy Results from the OPTIC Trial

Transformer-Based Method for Visualization and Quantification of 3-D Human Retinal Circulation from Single Volume in Commercial OCT

Detection of Double Layer Sign in OCT using a 3D foundation model

In Situ Hybridization Demonstrates Ocular Distribution of Ixo-vec IVT Gene Therapy in Human Cadaver Eyes with wAMD and Supports Durable Clinical Efficacy

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

Fully Automated OCT-based Tissue Screening System

Reveal retinal ultra-structure with self-supervised denoising in vis-OCT

Differences in Systemic Pulse Waveform Between Individuals With Glaucoma, Glaucoma Suspects, and Healthy Controls

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