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Immunology and Microbiology February 2025

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

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Jiamin Liu; Min Kang; Yuan Wei; Zijun Zhang; Jinding Pang; Qiankun Chen; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: genes, genome, keratitis, virulence, aspergillus flavus, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):42. https://doi.org/10.1167/iovs.66.2.42

Includes: Supplemental Content

Cornea & External Disease January 2025

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

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Yan Peng; Qiankun Chen; Yuan Wei; Leying Wang; Zijun Zhang; Zhenyu Wei; Jinding Pang; Bo Peng; Qingquan Shi; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Qingfeng Liang
TAGS: candida, keratitis, hyphae, plant spores, reproduction spores
Trans. Vis. Sci. Tech.. 2025; 14(1):23. https://doi.org/10.1167/tvst.14.1.23

Includes: Supplemental Content

Immunology and Microbiology March 2024

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

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Xiaoyan Guo; Zijun Zhang; Qiankun Chen; Leying Wang; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: cornea, genes, keratitis, nocardia, family
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):26. https://doi.org/10.1167/iovs.65.3.26

Includes: Supplemental Content

Cornea February 2024

Ferroptosis as a Potential Therapeutic Target for Reducing Inflammation and Corneal Scarring in Bacterial Keratitis

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Qiankun Chen; Leying Wang; Yuan Wei; Xizhan Xu; Xiaoyan Guo; Qingfeng Liang
TAGS: bacterial keratitis, cicatrix, cornea, ferroptosis, inflammation, mice, iron
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):29. https://doi.org/10.1167/iovs.65.2.29

Includes: Supplemental Content

Cornea & External Disease February 2024

Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations

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Jinding Pang; Zhenyu Wei; Leying Wang; Xiaoyan Guo; Qiankun Chen; Yuan Wei; Yan Peng; Zijun Zhang; Yuheng Zhang; Jiamin Liu; Zhen Cheng; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Xinxin Lu; Qingfeng Liang
TAGS: acanthamoeba, acanthamoeba keratitis, china, genotype, signs and symptoms
Trans. Vis. Sci. Tech.. 2024; 13(2):5. https://doi.org/10.1167/tvst.13.2.5

Includes: Supplemental Content

Cornea September 2023

Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway

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Leying Wang; Xizhan Xu; Qiankun Chen; Yuan Wei; Zhenyu Wei; Zi-Bing Jin; Qingfeng Liang
TAGS: cornea, epithelial stem cells, extracellular vesicles, mesenchymal stem cells, micrornas, phenotype
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):42. https://doi.org/10.1167/iovs.64.12.42

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Probiotic Bacterial Metabolite Inhibits NFκB Activation Induced by Toll-like Receptor 5 Agonist on Human Corneal Epithelial Cells

Ping Bu; Michelle Seu; Charles Bouchard; Liang Qiao

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1719.

ARVO Annual Meeting Abstract June 2023

Single cell atlas of the human retina

Jin Li; Jun Wang; Xuesen Cheng; Ignacio Ibarra; Malte Luecken; Qingnan Liang; Fabian Theis; Margaret M DeAngelis; Yumei Li; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3268.

Immunology and Microbiology May 2023

Metagenomic Sequencing Analysis Identifies Cross-Cohort Gut Microbial Signatures Associated With Age-Related Macular Degeneration

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Wei Xue; Peiyao Peng; Xiaofeng Wen; Huan Meng; Yali Qin; Tingting Deng; Shixin Guo; Tingting Chen; Xifang Li; Juanran Liang; Feng Zhang; Zhi Xie; Ming Jin; Qiaoxing Liang; Lai Wei
TAGS: age-related macular degeneration, cohort studies, datasets, dysbiosis, microbiome, chinese (other dialects), bacteriophages, chinese people
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):11. https://doi.org/10.1167/iovs.64.5.11

Includes: Supplemental Content

Immunology and Microbiology March 2023

Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis

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Xizhan Xu; Yuan Wei; Jinding Pang; Zhenyu Wei; Leying Wang; Qiankun Chen; Zhiqun Wang; Yang Zhang; Kexin Chen; Yan Peng; Zijun Zhang; Jiamin Liu; Yuheng Zhang; Zi-Bing Jin; Qingfeng Liang
TAGS: cornea, fungal keratitis, immune response, mice, mycoses, time factors, genes, infections, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):6. https://doi.org/10.1167/iovs.64.3.6

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Nectin-1 and NMHC-IIB: major mediators of HSV-1 entry into corneal nerves.

chenchen wang; Yun He; Qi Liang; Kai Hu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3966 – A0246.

ARVO Annual Meeting Abstract June 2022

MSC-EVs treat dry eye disease by regulating dendritic cells and promoting tissue repair

Rongjie Guo; Jiaxuan Jiang; chenchen wang; Qi Liang; Kai Hu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1978 – A0308.

ARVO Annual Meeting Abstract June 2022

Deciphering non-coding genetic variants via integrative single cell multi-omics analysis

Rui Chen; Jun Wang; Xuesen Cheng; Qingnan Liang; Jun Wang; Margaret M DeAngelis; Yumei Li

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3.

ARVO Annual Meeting Abstract June 2022

Integrating gene regulation and single cell expression with genetic associations identifies genes and cell types contributing to primary open angle glaucoma risk and intraocular pressure

Ayellet Vered Segre; Andrew R Hamel; Jiali Wang; John Rouhana; Tavé van Zyl; Wenjun Yan; Alexi mcadams; Aboozar Monavarfeshani; Qingnan Liang; Rui Chen; Joshua R. Sanes; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1132.

ARVO Annual Meeting Abstract June 2022

A single cell multi-omics atlas of the human retina

Xuesen Cheng; Qingnan Liang; Jun Wang; Leah A Owen; Yumei Li; Margaret M DeAngelis; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2311.

ARVO Annual Meeting Abstract June 2022

Soft clustering analysis of primary open angle glaucoma loci and their association with multiple endophenotypes uncovers pathophysiological and cellular mechanisms of disease

jacqueline F ohmura; Claire Kim; Andrew R Hamel; Tave A van Zyl; wenjun yan; Alexi mcadams; Aboozar Monavarfeshani; Qingnan Liang; Rui Chen; Joshua R. Sanes; Miriam udler; Janey L Wiggs; Ayellet Vered Segre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2049 – A0490.

Clinical Trials September 2021

Characteristics of Toxic Keratopathy, an In Vivo Confocal Microscopy Study

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Leying Wang; Yang Zhang; Zhenyu Wei; Kai Cao; Guanyu Su; Pedram Hamrah; Antoine Labbe; Qingfeng Liang
TAGS: basal cells, cornea, keratocytes, microscopy, confocal, neurons, finnish congenital nephrotic syndrome, slit lamps, eyedrops, signs and symptoms
Trans. Vis. Sci. Tech.. 2021; 10(11):11. https://doi.org/10.1167/tvst.10.11.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Integrative analysis of single-cell multi-omics data of the human retina

Qingnan Liang; Xuesen Cheng; Leah Owen; Akbar Shakoor; Albert T Vitale; Nadine Husami; Denise Morgan; Michael H Farkas; Ivana K Kim; Yumei Li; Margaret M DeAngelis; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1555.

Articles June 2021

Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study

PDF

Zhenyu Wei; Kai Cao; Leying Wang; Christophe Baudouin; Antoine Labbé; Qingfeng Liang
TAGS: acanthamoeba keratitis, cornea, cysts, keratitis, acanthamoeba
Trans. Vis. Sci. Tech.. 2021; 10(7):10. https://doi.org/10.1167/tvst.10.7.10

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Single-nuclei RNA-seq provides comprehensive transcriptomic classification of human retinal cell types.

Xuesen Cheng; Qingnan Liang; Leah A. Owen; Akbar Shakoor; Albert T Vitale; Ivana K Kim; Denise J. Morgan; Yumei Li; Margaret M DeAngelis; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1956.

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kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Ferroptosis as a Potential Therapeutic Target for Reducing Inflammation and Corneal Scarring in Bacterial Keratitis

Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations

Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway

Probiotic Bacterial Metabolite Inhibits NFκB Activation Induced by Toll-like Receptor 5 Agonist on Human Corneal Epithelial Cells

Single cell atlas of the human retina

Metagenomic Sequencing Analysis Identifies Cross-Cohort Gut Microbial Signatures Associated With Age-Related Macular Degeneration

Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis

Nectin-1 and NMHC-IIB: major mediators of HSV-1 entry into corneal nerves.

MSC-EVs treat dry eye disease by regulating dendritic cells and promoting tissue repair

Deciphering non-coding genetic variants via integrative single cell multi-omics analysis

Integrating gene regulation and single cell expression with genetic associations identifies genes and cell types contributing to primary open angle glaucoma risk and intraocular pressure

A single cell multi-omics atlas of the human retina

Soft clustering analysis of primary open angle glaucoma loci and their association with multiple endophenotypes uncovers pathophysiological and cellular mechanisms of disease

Characteristics of Toxic Keratopathy, an In Vivo Confocal Microscopy Study

Integrative analysis of single-cell multi-omics data of the human retina

Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study

Single-nuclei RNA-seq provides comprehensive transcriptomic classification of human retinal cell types.

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