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Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

ARMMs as non-viral vehicles for the delivery of genome editors to treat Stargardt disease

Jinling Yang; Chou-Wei Chang; Qiyu Wang; Wendy Zhao; Adam Miller; Shu-Lin Liu; Lucy (Yumei) Sun; Alysia Bryant; Steven Greenway; Adam Francoeur; Leah Gens; Kristin Luther; Gary Hao; Yashodhan Chinchore; Qin Yu; Joseph Nabhan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2227.

ARVO Annual Meeting Abstract June 2024

Structure-based network analysis identifies pathogenic variants in patients with inherited retinal disease

Blake M. Hauser; Yuyang Luo; Anusha Nathan; Demetrios Vavvas; Jason Comander; Eric A Pierce; Emily Place; Kinga Maria Bujakowska; Gaurav D Gaiha; Elizabeth J Rossin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6029.

ARVO Annual Meeting Abstract June 2024

Elevated IOP reduces lamina cribrosa oxygenation both directly through capillary distortion and indirectly by reducing perfusion from the posterior ciliary arteries

Yuankai Lu; Hasan Banna; Hua Yi; Hannah Schilpp; Mingna Liu; Fuqiang Zhong; Bingrui Wang; Andrew theophanous; Shaharoz Tahir; Po-Yi Lee; Joel R Palko; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):392.

ARVO Annual Meeting Abstract June 2024

Axons passing through small LC pores suffer larger IOP-induced distortions than those through large pores

Bingrui Wang; Susannah Waxman; Sofia Lusvardi; Yuankai Lu; Yingzhe Han; Ashley Ray Linton; Tian Qi; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1205.

ARVO Annual Meeting Abstract June 2024

Evaluating the effects of fiber force dissipation for predicting the effects of modulating the mechanical properties of lamina cribrosa and sclera

Yingzhe Han; Bingrui Wang; Xuehuan He; Yuankai Lu; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1203.

ARVO Annual Meeting Abstract June 2024

Ultralocal subretinal immunosuppressive nanoparticles to abrogate graft rejection in retinal cell therapy

Kang Li; Ying Liu; Wathsala Liyanage; Anjali Sharma; Bani Antonio-Aguirre; Yuchen Lu; Zhuolin Li; Krystal Yearis; Kenneth Jimenez; Boaz Goldberg; Sally Li; Annabelle Pan; Minda Mcnally; Kannan Rangaramanujam; Mandeep S Singh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):709.

ARVO Annual Meeting Abstract June 2024

Inter-photoreceptor transfer of phototransduction and disc rim proteins correlates with improvement in retinal function

Ying Liu; Kang Li; Bani Aguirre; Kenneth Jimenez; Sally Li; Edward Esposito; Minda Mcnally; Yuchen Lu; Zhuolin Li; Mandeep Singh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2196.

ARVO Annual Meeting Abstract June 2024

Genome-wide association study (GWAS) of anti-VEGF treatment response in diabetic macular edema identifies genetic associations with retina central subfield thickness and visual acuity improvement

Yuyang Luo; Jiali Wang; Danni Liu; Sandra Galusic; Jacqueline Otto; Eli Stahl; Amelia J. Averitt; Giovanni Coppola; Jennifer K Sun; Adam Glassman; Lucia Sobrin; Ayellet Segre

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4881.

ARVO Annual Meeting Abstract June 2024

Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

Yuancheng Ryan Lu; Margarete Karg; Lindsey A Chew; Kat Kajderowicz; Daisy Y Shu; Xiaojie Qiu; Nasrin Refaian; Shintaro Shirahama; Zhengping Hu; Tessa Bertozzi; David Sinclair; Magali Saint-Geniez; Patricia A D'Amore; Catherine Bowes Rickman; Bruce Ksander; Jonathan Weissman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5307.

Glaucoma May 2024

The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure

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Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A. Sigal
TAGS: alveolar ventilation function, cell respiration, compression, perfusion, raised intraocular pressure, vasculature, hemodynamics, vascular flow, optic disk, oxygen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):1. https://doi.org/10.1167/iovs.65.5.1

Artificial Intelligence April 2024

Trends in the Prevalence of Common Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

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Ruiheng Zhang; Li Dong; Xuefei Fu; Lin Hua; Wenda Zhou; Heyan Li; Haotian Wu; Chuyao Yu; Yitong Li; Xuhan Shi; Yangjie Ou; Bing Zhang; Bin Wang; Zhiqiang Ma; Yuan Luo; Meng Yang; Xiangang Chang; Zhaohui Wang; Wenbin Wei
TAGS: artificial intelligence, china, optic nerve disorders, prevalence, screening, trend
Trans. Vis. Sci. Tech.. 2024; 13(4):28. https://doi.org/10.1167/tvst.13.4.28

Includes: Supplemental Content

Retina December 2023

Transition to Chronic Fibrosis in an Animal Model of Retinal Detachment With Features of Proliferative Vitreoretinopathy

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Cornelia Peterson; Yuchen Lu; Clayton P. Santiago; Antoinette C. Price; Minda M. McNally; William Schubert; Khaled Nassar; Thomas Zollner; Seth Blackshaw; Charles G. Eberhart; Mandeep S. Singh
TAGS: animal model, fibrosis, gene expression, histology, retinal detachment, rhegmatogenous retinal detachment, tissue membrane, vitreoretinopathy, proliferative, oryctolagus cuniculus, fibrillar collagen
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):39. https://doi.org/10.1167/iovs.64.15.39

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Non-human primate laser-induced NAION model for assessing neuro-rejuvenating gene therapies

Madhura Shah; Drenushe Krasniqi; Meredith S Gregory-Ksander; Sharon Rosenzweig-Lipson; Kasia Broniowska; Michel Wathier; Joan Mannick; Jennifer Cermak; Margarete Karg; Shintaro Shirahama; Nasrin Refaian; Yuancheng Lu; Bruce Ksander; Matthew Lawrence; David Sinclair; Joseph F. Rizzo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5223.

ARVO Annual Meeting Abstract June 2023

Reproducibility of ellipsoid zone (EZ) parameters measured under different OCT scan settings in retinitis pigmentosa (RP)

Xiangrong Kong; Kevin Choy; Muhammad Khan; Yuchen Lu; Dagmar Wehling; Peter A Campochiaro; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4659.

ARVO Annual Meeting Abstract June 2023

Investigating gene regulatory networks controlling retinal fibrosis in a rabbit model of proliferative vitreoretinopathy

Clayton Pio Santiago; Megan Gimmen; Yuchen Lu; Leighton Duncan; Taqdees Gohar; Cornelia W Peterson; Antionette Price; Minda McNally; Tyler Creamer; Linda Orzolek; Charles G. Eberhart; Jiang Qian; Seth Blackshaw; Mandeep S Singh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4566.

ARVO Annual Meeting Abstract June 2023

Systematic approach to analyzing protein structure predicts mutations associated with inherited retinal disease

Blake M. Hauser; Yuyang Luo; Anusha Nathan; James Chodosh; Lucia Sobrin; Eric A Pierce; Bruce Walker; Gaurav Gaiha; Elizabeth Rossin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3267.

ARVO Annual Meeting Abstract June 2023

Moderately elevated IOP may alter optic nerve head hemodynamics enough to cause mild hypoxia over a substantial part of the lamina cribrosa

Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4732.

ARVO Annual Meeting Abstract June 2023

Baseline visual field patterns identified by archetypal analysis are associated with glaucoma onset and progression in the Ocular Hypertension Treatment Study

Rishabh Singh; Yan Zhao; John H Fingert; Mae O Gordon; Michael A Kass; Yuyang Luo; Ayellet V. Segre; Janey L Wiggs; Tobias Elze; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):349.

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Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

ARMMs as non-viral vehicles for the delivery of genome editors to treat Stargardt disease

Structure-based network analysis identifies pathogenic variants in patients with inherited retinal disease

Elevated IOP reduces lamina cribrosa oxygenation both directly through capillary distortion and indirectly by reducing perfusion from the posterior ciliary arteries

Axons passing through small LC pores suffer larger IOP-induced distortions than those through large pores

Evaluating the effects of fiber force dissipation for predicting the effects of modulating the mechanical properties of lamina cribrosa and sclera

Ultralocal subretinal immunosuppressive nanoparticles to abrogate graft rejection in retinal cell therapy

Inter-photoreceptor transfer of phototransduction and disc rim proteins correlates with improvement in retinal function

Genome-wide association study (GWAS) of anti-VEGF treatment response in diabetic macular edema identifies genetic associations with retina central subfield thickness and visual acuity improvement

Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure

Trends in the Prevalence of Common Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

Transition to Chronic Fibrosis in an Animal Model of Retinal Detachment With Features of Proliferative Vitreoretinopathy

Non-human primate laser-induced NAION model for assessing neuro-rejuvenating gene therapies

Reproducibility of ellipsoid zone (EZ) parameters measured under different OCT scan settings in retinitis pigmentosa (RP)

Investigating gene regulatory networks controlling retinal fibrosis in a rabbit model of proliferative vitreoretinopathy

Systematic approach to analyzing protein structure predicts mutations associated with inherited retinal disease

Moderately elevated IOP may alter optic nerve head hemodynamics enough to cause mild hypoxia over a substantial part of the lamina cribrosa

Baseline visual field patterns identified by archetypal analysis are associated with glaucoma onset and progression in the Ocular Hypertension Treatment Study

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