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Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Retina October 2024

Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa

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Subrata Batabyal; Sanghoon Kim; Michael Carlson; Darryl Narcisse; Kissaou Tchedre; Adnan Dibas; Najam A. Sharif; Samarendra Mohanty
TAGS: intravitreal injections, mice, retina, retinal degeneration, vision, injections, tissue degeneration
Trans. Vis. Sci. Tech.. 2024; 13(10):25. https://doi.org/10.1167/tvst.13.10.25

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Müller glia derived EVs promote recovery in Retinal ganglion like cells derived from hESC Retinal organoids in vitro

Karen Eastlake; William Lamb; Najam (Naj) Sharif; Tero Valimaa; Hari Jayaram; G. Astrid Limb

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4538.

ARVO Annual Meeting Abstract June 2024

Multi-characteristic opsin gene therapy attenuates retinal degeneration and restore vision in mouse models of retinitis pigmentosa

Subrata Batabyal; Sanghoon Kim; Michael Carlson; Darryl Narcisse; Kissaou Tchedre; Adnan Dibas; Najam (Naj) Sharif; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5356.

ARVO Annual Meeting Abstract June 2024

In vivo efficacy of a novel multi-characteristic opsin (MCO-010) in a mouse model of Leber congenital amaurosis

Najam (Naj) Sharif; Subrata Batabyal; Adnan Dibas; Michael Carlson; Sanghoon Kim; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6096.

ARVO Annual Meeting Abstract June 2024

Characterization of a broadband ambient light activatable multi-characteristic opsin supporting its superior performance in restoring vision

Samarendra Mohanty; Pratyajit Mohapatra; Amir Singh; Subrata Batabyal; Michael Carlson; Sanghoon Kim; Najam (Naj) Sharif

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6078.

ARVO Annual Meeting Abstract June 2023

Molecular and functional characterization of extracellular vesicles derived from Muller glia cells

William Lamb; Karen Eastlake; Joshua Luis; Peng Tee Khaw; Najam (Naj) Sharif; G. Astrid Limb

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1562.

ARVO Annual Meeting Abstract June 2023

hESC-derived Retinal organoids for in vitro modelling of retinal ganglion cell death

Karen Eastlake; William D.B Lamb; Najam (Naj) Sharif; G. Astrid Limb

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3170.

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2020

Chemically-induced Retinal Degeneration in Mice with Autophagy Dysfunction

Merry Gunawan; Choon Bing Low; Naj Sharif; Masaaki Kageyama

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):668.

ARVO Annual Meeting Abstract September 2016

Contractile Effects of Serotonergic Receptor Agonists and Antagonists on Isolated Bovine Ciliary Arteries.

Naj Sharif; Ya Fatou Njie-Mbye; Sunny E Ohia; Madura Kulkarni-Chitnis

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4596.

ARVO Annual Meeting Abstract April 2014

BK2A78: A novel non-peptide bradykinin B2 agonist lowers intraocular pressure (IOP) in ocular hypertensive cynomolgus monkeys.

Ganesh Prasanna; Naj Sharif; Byron H Li; Mark Hellberg; Terri Krause; Shenouda Yacoub; Daniel Scott; Curtis R Kelly; Iok-Hou Pang; Keith Combrink

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2883.

ARVO Annual Meeting Abstract April 2014

Pharmacological Evidence for Serotonin-2B Receptor-Mediated Bovine Ciliary Muscle Contraction.

Naj Sharif; Madura Kulkarni-Chitnis; Ya Fatou Njie-Mbye; Sunny E Ohia

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3024.

ARVO Annual Meeting Abstract June 2013

BK2A77: A novel non-peptide bradykinin B2 agonist lowers intraocular pressure in ocular hypertensive cynomolgus monkeys

Ganesh Prasanna; Naj Sharif; Byron Li; Curtis Kelly; Shouxi Xu; Linya Li; Daniel Scott; Rad Daly; Mark Hellberg; Keith Combrink

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1989.

ARVO Annual Meeting Abstract June 2013

Peptide and Non-Peptide Bradykinin (BK) Agonists and Antagonists Help Define Functional BK Receptors in Human Trabecular Meshwork and Ciliary Body

Naj Sharif; Parvaneh Katoli; Curtis Kelly; Linya Li; Shouxi Xu; Yu Wang; Ganesh Prasanna; Keith Combrink; Mark Hellberg; Shahid Husain

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1997.

ARVO Annual Meeting Abstract March 2012

Ciliary Muscle (CM) Bradykinin B2-Receptors: Protein Expression, Pharmacology of Biochemical Signaling Processes and Relation to IOP Modulation

Naj Sharif; Parvaneh Katoli; Linya Li; Shouxi Xu; Curtis Kelly; Richard Ornberg; Yu Wang; Laura Klekar; Daniel Scott; Shahid Husain

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3671.

ARVO Annual Meeting Abstract March 2012

Activation Of Erk Signaling Pathway By Bradykinin B2 Receptors In Isolated Human Primary Ciliary Muscle Cells

Rajkumar V. Patil; Linya Li; Naj Sharif

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1971.

ARVO Annual Meeting Abstract April 2011

Natural History of Collagen and Endothelial Markers in Mouse Laser-induced CNV/Subretinal Fibrosis

Changdong Liu; Yu Wang; Shutong Cao; Rosalyn Le; David P. Bingaman; Richard Ornberg; Naj Sharif; Carl Romano

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1786.

ARVO Annual Meeting Abstract April 2011

Signal Transduction in Cultured Human Iridial Melanocytes and Fibroblasts

Naj Sharif; Julie Crider

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2055.

ARVO Annual Meeting Abstract April 2011

Expression Of Cellular Biomarkers In Subretinal Fibrosis In The Mouse Laser-induced CNV Model

Yu Wang; Changdong Liu; Shutong Cao; Rosalyn Le; David P. Bingaman; Richard Ornberg; Naj A. Sharif; Carl Romano

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1787.

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Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa

Müller glia derived EVs promote recovery in Retinal ganglion like cells derived from hESC Retinal organoids in vitro

Multi-characteristic opsin gene therapy attenuates retinal degeneration and restore vision in mouse models of retinitis pigmentosa

In vivo efficacy of a novel multi-characteristic opsin (MCO-010) in a mouse model of Leber congenital amaurosis

Characterization of a broadband ambient light activatable multi-characteristic opsin supporting its superior performance in restoring vision

Molecular and functional characterization of extracellular vesicles derived from Muller glia cells

hESC-derived Retinal organoids for in vitro modelling of retinal ganglion cell death

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Chemically-induced Retinal Degeneration in Mice with Autophagy Dysfunction

Contractile Effects of Serotonergic Receptor Agonists and Antagonists on Isolated Bovine Ciliary Arteries.

BK2A78: A novel non-peptide bradykinin B2 agonist lowers intraocular pressure (IOP) in ocular hypertensive cynomolgus monkeys.

Pharmacological Evidence for Serotonin-2B Receptor-Mediated Bovine Ciliary Muscle Contraction.

BK2A77: A novel non-peptide bradykinin B2 agonist lowers intraocular pressure in ocular hypertensive cynomolgus monkeys

Peptide and Non-Peptide Bradykinin (BK) Agonists and Antagonists Help Define Functional BK Receptors in Human Trabecular Meshwork and Ciliary Body

Ciliary Muscle (CM) Bradykinin B2-Receptors: Protein Expression, Pharmacology of Biochemical Signaling Processes and Relation to IOP Modulation

Activation Of Erk Signaling Pathway By Bradykinin B2 Receptors In Isolated Human Primary Ciliary Muscle Cells

Natural History of Collagen and Endothelial Markers in Mouse Laser-induced CNV/Subretinal Fibrosis

Signal Transduction in Cultured Human Iridial Melanocytes and Fibroblasts

Expression Of Cellular Biomarkers In Subretinal Fibrosis In The Mouse Laser-induced CNV Model

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