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Cornea June 2025

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

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Yue Li; Boyu Yang; Qi Chen; Yuchen Zhou; Wen Hu; Xiaojia Huang; Guangyi Huang; Ningning Tang; Fen Tang; Hui Huang; Qianqian Lan; Wenjing He; Fan Xu; Yiming Ye; Li Jiang
TAGS: alkalies, burns, cornea, corneal neovascularization, macrophages, necroptosis, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):54. https://doi.org/10.1167/iovs.66.6.54

Includes: Supplemental Content

Cornea May 2025

Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

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Dongfang Li; Haoyun Duan; Xinhang Wang; Zhan Lin; Kun Dai; Xiangyue Hu; Xintian Zhao; Qingjun Zhou; Zongyi Li; Lixin Xie
TAGS: chronic exertional compartment syndrome, cornea, endothelium, finite element analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):33. https://doi.org/10.1167/iovs.66.5.33

Retina April 2025

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

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Jie Xu; Yi Li; Xiangyu Li; Xuan Tan; Lihua Liu; Lining Cao; Hui Xu
TAGS: interleukin-6, retina, zebrafish, microglia, signal transduction, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):67. https://doi.org/10.1167/iovs.66.4.67

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu
TAGS: angiogram, atypical, eye, genetics, retinal capillary hemangioma, von hippel-lindau syndrome, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):34. https://doi.org/10.1167/iovs.66.4.34

Includes: Supplemental Content

Pediatric Ophthalmology & Strabismus March 2025

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

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Wenyan Xu; Xiaoman Li; Jianing Zhang; Hongyi Li; Xuewen Ding; Xiaoyue Hu; Xinyue Quan; Yue Su; Fan Lu; Jie Chen
TAGS: astigmatism, child, lens (device), lens, crystalline, myopia, refractive errors
Trans. Vis. Sci. Tech.. 2025; 14(3):8. https://doi.org/10.1167/tvst.14.3.8

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Cornea & External Disease February 2025

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

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Debbie Marie Ng; Xiu Wang; Chang Liu; MingYi Yu; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Regina Kay Ting Wong; Diana Xin Hui Chan; Yu-Chi Liu; Louis Hak Tien Tong
TAGS: ocular pain, pain, rasch model, reliability, surveys
Trans. Vis. Sci. Tech.. 2025; 14(2):20. https://doi.org/10.1167/tvst.14.2.20

Includes: Supplemental Content

Cornea February 2025

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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Xiao Zhou; Lingjuan Xu; Yongyao Tan; Wei Wang; Xiaoyu Huang; Guigang Li
TAGS: language morphology, morphology, phenotype, translocation (genetics), diffuse idiopathic skeletal hyperostosis, cornea, stem cells, proteins, western blotting, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):43. https://doi.org/10.1167/iovs.66.2.43

Includes: Supplemental Content

Cornea February 2025

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

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Xiaojuan Hu; Jiayao Feng; Chengjie Pan; Zhenzhen Sun; Jiechen Liu; Shuang Xie; Decheng Xiao; Xiaoyin Ma; Qinxiang Zheng; Wei Chen
TAGS: dry eye syndromes, hmgb1 protein, lysosomes, borderline neoplasms, apoptosis, homeostasis, cell death, stress, date of last normal period, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):5. https://doi.org/10.1167/iovs.66.2.5

Retina January 2025

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

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Jinlian Zhan; Chen Chen; Tong Wang; Qi Zhang; Xia Huang; Lin Lu; Xiujuan Zhao
TAGS: epiretinal membrane, perfusion, postoperative care, preoperative care, recovery of function, retinal vasculature, vision, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(1):19. https://doi.org/10.1167/tvst.14.1.19

Includes: Supplemental Content

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Retina November 2024

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

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Juan Zhang; Lu Ruan; Chen Jiang; Qian Yang; Qing Chang; Xin Huang
TAGS: familial exudative vitreoretinopathies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):4. https://doi.org/10.1167/iovs.65.13.4

Includes: Supplemental Content

Retinal Cell Biology October 2024

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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Mei-Ling Gao; Tong-Yu Wang; Xin Lin; Chun Tang; Mengyao Li; Zhan-Pei Bai; Zhi-Cong Liu; Li-Jun Chen; Qing-Ran Kong; Shao-Hui Pan; Shan-Shan Zeng; Ya Guo; Jian-Qi Cai; Xiu-Feng Huang; Jun Zhang
TAGS: foreign medical graduates, microglia, organoids, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):19. https://doi.org/10.1167/iovs.65.12.19

Includes: Supplemental Content

Retina August 2024

IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration

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Hong Zhou; Yan Liu; Tian Zhou; Ziqi Yang; Biyan Ni; Yang Zhou; Huiyi Xu; Xiaojing Lin; Shiya Lin; Chang He; Xialin Liu
TAGS: exosomes, interleukin-23, mesenchymal stem cells, micrornas, neuroprotective effect, retinal degeneration, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):8. https://doi.org/10.1167/iovs.65.10.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Ensemble Learning-based AI Model for Alzheimer's Disease Detection from En Face Images, Thickness and Deviation Maps of OCT Tomography

Carol Yim-Lui Cheung; Anran Ran; Xiaoyan Hu; Herbert Hui; Christopher Chen; Vincent Mok; Tien Y Wong

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2831.

ARVO Annual Meeting Abstract June 2024

An interpretable deep learning model for detection of referable/non-referable diabetic retinopathy: a retrospective, multicenter study

Xiaoyan Hu; Anran Ran; Gabriel YANG; Truong Xuan Nguyen; Sobha Sivaprasad; Gavin S Tan; Simon Szeto; Carol Cheung

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1597.

ARVO Annual Meeting Abstract June 2024

Epidemiology and Predictive Modelling for Moderate-to-severe Thyroid Eye Disease in Hong Kong – a Territory-wide study of 140,776 Autoimmune Thyroid Disease Patients

Wai Chak Choy; Xiaoyan Hu; Oscar Hou In Chou; Han Wang; Kenneth K.H. Lai; Fatema Mohamed Ali Abdulla Aljufairi; Hunter Yuen; Carman Chan; Wilson Yip; Alvin L. Young; Carol Cheung; Calvin C P Pang; Clement C. Tham; Kam-Lung, Kelvin Chong

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3049.

ARVO Annual Meeting Abstract June 2024

TRPV1-Targeted Hydrogel against Pyroptosis of Dry Eye Disease In Vitro and In Vivo

Xiangyu Ding; Xia Hua

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5745.

ARVO Annual Meeting Abstract June 2024

Caspase-1-Dependent Pyroptosis of Human Corneal Epithelial Cells Promotes RIP3/MLKL Mediated Necroptosis in the Pathogenesis of Dry Eye

Xia Hua; Xiangyu Ding; Jingqing Mu; Baoyue Mi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5744.

ARVO Annual Meeting Abstract June 2024

Integration of vitreous metabolomics and lipidomics for vitreous-retina adhension in proliferative diabetic retinopathy

Ying Cui; Zhongning Huang; Lei Xi; Anyi Liang; Liang Zhang; Mingsi Chi; Tai Guo; Yue Liu; Xiaofeng Huang; Yuman Li; Zhixin Mo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):OD66.

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RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration

Ensemble Learning-based AI Model for Alzheimer's Disease Detection from En Face Images, Thickness and Deviation Maps of OCT Tomography

An interpretable deep learning model for detection of referable/non-referable diabetic retinopathy: a retrospective, multicenter study

Epidemiology and Predictive Modelling for Moderate-to-severe Thyroid Eye Disease in Hong Kong – a Territory-wide study of 140,776 Autoimmune Thyroid Disease Patients

TRPV1-Targeted Hydrogel against Pyroptosis of Dry Eye Disease In Vitro and In Vivo

Caspase-1-Dependent Pyroptosis of Human Corneal Epithelial Cells Promotes RIP3/MLKL Mediated Necroptosis in the Pathogenesis of Dry Eye

Integration of vitreous metabolomics and lipidomics for vitreous-retina adhension in proliferative diabetic retinopathy

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