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Retina January 2025

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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Yan Wang; Dehuan Xu; Yuhang Zhao; Haiyu Zhu; Xiaoyu Xiu; Haiyan Jiang; Yimei Liu; Ge Shan; Shengzhou Wu
TAGS: mice, proteins, retina, serine, alzheimer's disease, regulation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):36. https://doi.org/10.1167/iovs.66.1.36

Includes: Supplemental Content

Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Article January 2025

Eye posture and screen alignment with simulated see-through head-mounted displays

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Agostino Gibaldi; Yinghua Liu; Christos Kaspiris-Rousellis; Madhumitha S. Mahadevan; Jenny C. A. Read; Björn N. S. Vlaskamp; Gerrit W. Maus
TAGS: eye, posture
Journal of Vision. 2025; 25(1):9. https://doi.org/10.1167/jov.25.1.9

Includes: Supplemental Content

Retina January 2025

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

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Shizhen Lei; Yani Liu
TAGS: gastrointestinal microbiome, genetic correlation analysis, genetics, mendelian randomization analysis, retinal vein occlusion
Trans. Vis. Sci. Tech.. 2025; 14(1):5. https://doi.org/10.1167/tvst.14.1.5

Includes: Supplemental Content

Lens January 2025

Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery

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Chang Liu; Xinyue Wang; Hon Shing Ong; Marcus Ang; Soon-Phaik Chee; Jianhong Ching; Kee Voon Chua; Sharon Hong Yu Han; Jodhbir S. Mehta; Lei Zhou; Yu-Chi Liu
TAGS: cataract surgery, lasers, metabolomics, proteins, proteomics, metabolites
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):10. https://doi.org/10.1167/iovs.66.1.10

Includes: Supplemental Content

Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Retinal Cell Biology November 2024

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

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Belinda J. Hernandez; Madison Strain; Maria Fernanda Suarez; W. Daniel Stamer; Allison Ashley-Koch; Yutao Liu; Mikael Klingeborn; Catherine Bowes Rickman
TAGS: micrornas, patient isolation, social isolation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):57. https://doi.org/10.1167/iovs.65.13.57

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

De-Differentiation of Corneal Epithelial Cells Into Functional Limbal Epithelial Stem Cells After the Ablation of Innate Stem Cells

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Yijian Li; Lingling Ge; Bangqi Ren; Xue Zhang; Zhiyuan Yin; Hongling Liu; Yuli Yang; Yong Liu; Haiwei Xu
TAGS: ablation, chronic exertional compartment syndrome, cornea, stem cells, epithelium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):32. https://doi.org/10.1167/iovs.65.13.32

Includes: Supplemental Content

Genetics November 2024

Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort

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Yufei Xu; Xiao Liu; Nan Wu; Yanling Long; Jiayun Ren; Yu Wang; Xinyi Su; Zengping Liu; Yu Fujinami-Yokokawa; Kaoru Fujinami; Fang Chen; Xiaohong Meng; Yong Liu
TAGS: cohort studies, crystal structure, disease progression, eye, fovea centralis, longitudinal studies, genotype, vision, blindness, mutation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):27. https://doi.org/10.1167/iovs.65.13.27

Includes: Supplemental Content

Retina October 2024

Preoperative Widefield Swept-Source Optical Coherence Tomography Versus Intraoperative Findings in Detecting Posterior Vitreous Detachment

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Zhuangling Lin; Kai Gao; Rebiya Tuxun; Chin-Ling Tsai; Zhuojun Xu; Lan Jiang; Yaping Liu; Ziye Chen; Zitong Chen; Baoyi Liu; Yuan Ma; Xiaoyue Wei; Kunbei Lai; Tao Li
TAGS: epiretinal membrane, intraoperative care, macular holes, optical coherence tomography, preoperative care, surgical procedures, operative, vitreous body, vitreous detachment, eye
Trans. Vis. Sci. Tech.. 2024; 13(10):39. https://doi.org/10.1167/tvst.13.10.39

Includes: Supplemental Content

Refractive Intervention October 2024

The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid

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Ying Liu; Mengxia Zhu; Xiaoqin Yan; Mu Li; Yan Xiang
TAGS: choroid, follow-up, myopia, red light
Trans. Vis. Sci. Tech.. 2024; 13(10):29. https://doi.org/10.1167/tvst.13.10.29

Includes: Supplemental Content

Retina October 2024

Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

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Xiao Xie; Wenqi Wang; Hongyan Wang; Zhiping Zhang; Xiaomeng Yuan; Yanmei Shi; Yanfeng Liu; Qingjun Zhou; Tingting Liu
TAGS: artificial intelligence, biological markers, diabetes mellitus, type 2, diabetic nephropathy, perfusion, screening, random forest, complex
Trans. Vis. Sci. Tech.. 2024; 13(10):19. https://doi.org/10.1167/tvst.13.10.19

Cornea October 2024

Mesenchymal Stem Cells-Derived Exosomal miR-223-3p Alleviates Ocular Surface Damage and Inflammation by Downregulating Fbxw7 in Dry Eye Models

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Guifang Wang; Yujie Zhu; Yuzhen Liu; Mulin Yang; Li Zeng
TAGS: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, dry eye syndromes, f-box-wd repeat-containing protein 7, fbxw7 gene, inflammation, mice, ocular surfaces, cornea
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):1. https://doi.org/10.1167/iovs.65.12.1

Includes: Supplemental Content

Cornea & External Disease September 2024

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

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Shi-Nan Wu; Xiao-Dong Chen; Qing-He Zhang; Yu-Qian Wang; Dan Yan; Chang-Sheng Xu; Shao-Pan Wang; Linfangzi Zhu; Dan-Yi Qin; Shu-Jia Guo; Lin Chen; Yu-Wen Liu; Caihong Huang; Jiaoyue Hu; Zuguo Liu
TAGS: keratitis, united states food and drug administration, incident reporting
Trans. Vis. Sci. Tech.. 2024; 13(9):17. https://doi.org/10.1167/tvst.13.9.17

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging September 2024

Characterizing Presumed Displaced Retinal Ganglion Cells in the Living Human Retina of Healthy and Glaucomatous Eyes

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Mary E. Marte; Kazuhiro Kurokawa; HaeWon Jung; Yan Liu; Marcel T. Bernucci; Brett J. King; Donald T. Miller
TAGS: diagnostic imaging, glaucoma, retina, eye, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):20. https://doi.org/10.1167/iovs.65.11.20

Includes: Multimedia, Supplemental Content

Letters to the Editor August 2024

Causal Association Between Lipid-Lowering Drugs and Glaucoma: A Drug-Targeted Mendelian Randomization Study

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Yaqiong Liu; Tao Li
TAGS: antilipemic agents, glaucoma, lipid-lowering therapy, mendelian randomization analysis
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):23. https://doi.org/10.1167/iovs.65.10.23

Includes: Supplemental Content

Visual Neuroscience August 2024

Macrophages Modulate Optic Nerve Crush Injury Scar Formation and Retinal Ganglion Cell Function

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Yuan Liu; Xiangxiang Liu; Christopher A. Dorizas; Zixuan Hao; Richard K. Lee
TAGS: cicatrix, macrophages, mice, optic nerve, crushing injuries, optic nerve injuries, retinal ganglion cells, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):22. https://doi.org/10.1167/iovs.65.10.22

Includes: Supplemental Content

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Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Eye posture and screen alignment with simulated see-through head-mounted displays

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

De-Differentiation of Corneal Epithelial Cells Into Functional Limbal Epithelial Stem Cells After the Ablation of Innate Stem Cells

Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort

Preoperative Widefield Swept-Source Optical Coherence Tomography Versus Intraoperative Findings in Detecting Posterior Vitreous Detachment

The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid

Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

Mesenchymal Stem Cells-Derived Exosomal miR-223-3p Alleviates Ocular Surface Damage and Inflammation by Downregulating Fbxw7 in Dry Eye Models

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

Characterizing Presumed Displaced Retinal Ganglion Cells in the Living Human Retina of Healthy and Glaucomatous Eyes

Causal Association Between Lipid-Lowering Drugs and Glaucoma: A Drug-Targeted Mendelian Randomization Study

Macrophages Modulate Optic Nerve Crush Injury Scar Formation and Retinal Ganglion Cell Function

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