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Lacrimal Apparatus, Eyelids, Orbit June 2025

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

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Huy Nguyen; Russell B. Fletcher; Tom Lopez; Elizabeth Whisler; Kelsey R. Logas; Navrose Dhaliwal; Timothy Suen; Mengrui Zhang; Archana Dilip; Tom Z. Yuan; Hayoung Go; Jay Ye; Parthasarathy Sampathkumar; Nick Suen; Hui Chen; Wen-Chen Yeh; Yang Li; Yorick Post
TAGS: lacrimal gland, ligation, acinar cells, mice, body tissue, wounds and injuries, organoids
Trans. Vis. Sci. Tech.. 2025; 14(6):19. https://doi.org/10.1167/tvst.14.6.19

Includes: Supplemental Content

Cornea June 2025

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

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Ning Wang; Yizhou Li; Xiaolei Wang; Lingling Yang; Jing Zhang; Jun Cheng; Xiaoyue Jiang; Xia Qi; Chao Wei; Qingjun Zhou; Ya Li; Suxia Li

Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):28. https://doi.org/10.1167/iovs.66.6.28

Includes: Supplemental Content

Retina June 2025

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

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Wenbo Zhang; Xuecong Zhou; Jiacheng Liu; Tian Tian; Yu Guo; Chen Ling; Jingjing Xu; Qijie Wei; Yang Liu; Yuan Wu
TAGS: arterial disease, brain, cadasil, infarction, leukoencephalopathies, retinal vessels, subcortical
Trans. Vis. Sci. Tech.. 2025; 14(6):17. https://doi.org/10.1167/tvst.14.6.17

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Cornea June 2025

Cornea Nerves Can Identify Different Types of Parkinson's Disease

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Dongyu Li; Xinyu Zhang; Fan Yang; Xin Jin; Shumin Li; Haonan Yuan; Lifen Yao; Hong Zhang
TAGS: cornea, nervousness, neurons, parkinson disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):21. https://doi.org/10.1167/iovs.66.6.21

Glaucoma June 2025

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

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Jianqi Chen; Xiaohua Zhuo; Yangjiani Li; Yingting Zhu; Zhidong Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Lei Lei
TAGS: body tissue, genes, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):7. https://doi.org/10.1167/iovs.66.6.7

Includes: Supplemental Content

Low Vision June 2025

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

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Lingling Yan; Ce Wu; Xiaona Liu; Pengfei Han; Jie Zhang; Zhipeng Gao; Xiaona Li; Weiyi Chen
TAGS: cross-linking, oryctolagus cuniculus, oxygen, sclera, safety
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):10. https://doi.org/10.1167/iovs.66.6.10

Includes: Supplemental Content

Glaucoma June 2025

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
TAGS: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2025; 14(6):6. https://doi.org/10.1167/tvst.14.6.6

Includes: Supplemental Content

Cornea & External Disease May 2025

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

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Yuke Huang; Jiejie Zhuang; Chang Liu; Shiji Liu; Huanhuan Ren; Qitong Zhang; Yan Li; Jin Qiu; Na Yu; Keming Yu; Xi Chen; Jing Zhuang
TAGS: genetics, keratoconus, obesity
Trans. Vis. Sci. Tech.. 2025; 14(5):20. https://doi.org/10.1167/tvst.14.5.20

Includes: Supplemental Content

Anatomy and Pathology/Oncology May 2025

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

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Jiahe Nie; Junjie Tang; Zhihui Zhang; Hetian Sun; Xinyue Wang; Longxiang Wang; Meng Wang; Weifeng Huang; Yang Gao; Jinmiao Li; Chao Cheng; Shicai Su; Shuxia Chen; Siming Ai; Yuxiang Mao; Ping Zhang; Yaoming Liu; Rong Lu
TAGS: oncogenes, retinoblastoma, tumor cell invasion, genes, cell lines, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):24. https://doi.org/10.1167/iovs.66.5.24

Includes: Supplemental Content

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina April 2025

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

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Yijie Yang; Jiawei Shen; Yanting Li; Xinzhu Chen; Gaoqin Liu; Peirong Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, choroid, epithelial to mesenchymal transition, fibrosis, mice, lasers, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):83. https://doi.org/10.1167/iovs.66.4.83

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Cornea & External Disease April 2025

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

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Jad F. Assaf; Jiachi Hong; Yan Li; David Huang
TAGS: cornea, incidence, optical coherence tomography, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(4):7. https://doi.org/10.1167/tvst.14.4.7

Uveitis April 2025

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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Hui Liu; Suo Guo; Yaning Liu; Guannan Su; Peizeng Yang
TAGS: chinese (other dialects), signs and symptoms, uveitis, anterior, chinese people, cytomegalovirus, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(4):2. https://doi.org/10.1167/tvst.14.4.2

Includes: Supplemental Content

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WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Cornea Nerves Can Identify Different Types of Parkinson's Disease

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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