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Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina April 2025

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

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Yijie Yang; Jiawei Shen; Yanting Li; Xinzhu Chen; Gaoqin Liu; Peirong Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, choroid, epithelial to mesenchymal transition, fibrosis, mice, lasers, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):83. https://doi.org/10.1167/iovs.66.4.83

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Cornea & External Disease April 2025

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

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Jad F. Assaf; Jiachi Hong; Yan Li; David Huang
TAGS: cornea, incidence, optical coherence tomography, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(4):7. https://doi.org/10.1167/tvst.14.4.7

Uveitis April 2025

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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Hui Liu; Suo Guo; Yaning Liu; Guannan Su; Peizeng Yang
TAGS: chinese (other dialects), signs and symptoms, uveitis, anterior, chinese people, cytomegalovirus, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(4):2. https://doi.org/10.1167/tvst.14.4.2

Includes: Supplemental Content

Cornea & External Disease March 2025

Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

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Jiachi Hong; Afshan A. Nanji; Richard D. Stutzman; Winston D. Chamberlain; Xubo Song; David Huang; Yan Li
TAGS: artificial intelligence, cornea, keratomileusis, laser in situ, maps, optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(3):17. https://doi.org/10.1167/tvst.14.3.17

Includes: Supplemental Content

Glaucoma March 2025

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

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Kunal Kanwar; Rithambara Ramachandran; Joshua D. Stein; Chris A. Andrews; Azraa S. Chaudhury; Maryam Ige; Xueqing Zhou; Shikha Marwah; Yang Li; Charlesnika T. Evans; Abel N. Kho; Paul J. Bryar; Dustin D. French; on behalf of the Sight Outcomes Research Collaborative (SOURCE) Consortium
TAGS: open-angle glaucoma, optic nerve, disease progression
Trans. Vis. Sci. Tech.. 2025; 14(3):15. https://doi.org/10.1167/tvst.14.3.15

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Retina March 2025

Ameboid Microglia as a Scavenger Role in Phagocytosis of Photoreceptor Outer Segment in an Experimental Retinal Detachment Model

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Manjing Cao; Yahan Zhang; Yan Li; Xian Zhang; Mingming Ma
TAGS: microglia, phagocytosis, photoreceptors, retinal detachment, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):4. https://doi.org/10.1167/iovs.66.3.4

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Cornea February 2025

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

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Fang Han; Leyi Wang; Jiayin Wu; Lin Shen; Yangyang Li; Hui Guo; Jianqiao Li
TAGS: keratitis, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, signal pathway, signal transduction pathways, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):13. https://doi.org/10.1167/iovs.66.2.13

Includes: Supplemental Content

Lens February 2025

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis

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Yan Liu; Xinyue Wang; Linghao Song; Yang Sun; Zexu Chen; Wannan Jia; Xin Shen; Yalei Wang; Xinyao Chen; Qiuyi Huo; Pranav Prakash Edavi; Tianhui Chen; Yongxiang Jiang
TAGS: ectopia lentis, eye, intelligence, intraocular lens implant device, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(2):5. https://doi.org/10.1167/tvst.14.2.5

Includes: Supplemental Content

Cornea February 2025

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

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Yanxiao Li; Zan Luo; Zihao Liu; Xinhao Zhu; Peter S. Reinach; Ling Li; Wei Chen
TAGS: dry eye syndromes, interleukin-23, conjunctiva, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):10. https://doi.org/10.1167/iovs.66.2.10

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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Lujue Wang; Yuan Li; Tongxin Niu; Jing Deng; Yuxian Shi; Yating Liu; Boding Tong; Xin Qi; Dan Cao; Yongguang Tao; Yunping Li
TAGS: ferroptosis, graves' ophthalmopathy, simvastatin, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):56. https://doi.org/10.1167/iovs.66.1.56

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Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

Ameboid Microglia as a Scavenger Role in Phagocytosis of Photoreceptor Outer Segment in an Experimental Retinal Detachment Model

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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