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Biochemistry and Molecular Biology May 2025

Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

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Jiali Guan; Guangliang Hong; Zhong Liu; Yingfeng Zheng; Jiangping He; Dajiang Qin; He Li
TAGS: fibroblasts, sclera, infant, single-cell rna-seq, dopamine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):29. https://doi.org/10.1167/iovs.66.5.29

Includes: Supplemental Content

Cornea & External Disease April 2025

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

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Shuaiyi Li; Yiping Liu; Bao Yang; Sulei Lv; Xiulan Zou; Liqun Tang; Licheng Zhou; Zhenyu Jiang; Zejia Liu
TAGS: catabolism, cornea, corneal edema, monte carlo method, transparency, fibril
Trans. Vis. Sci. Tech.. 2025; 14(4):15. https://doi.org/10.1167/tvst.14.4.15

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Immunology and Microbiology March 2025

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

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Minjie Zhang; Yichen Liang; Han Wu; Rongrong Zong; Xiaobo Zhang; Hui He; Peter Sol Reinach; Zuguo Liu; Long Shen; Wei Li
TAGS: dry eye syndromes, mice, ocular surfaces, sjogren's syndrome, conjunctiva, mice, transgenic
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):2. https://doi.org/10.1167/iovs.66.3.2

Includes: Supplemental Content

Cornea February 2025

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

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Yanxiao Li; Zan Luo; Zihao Liu; Xinhao Zhu; Peter S. Reinach; Ling Li; Wei Chen
TAGS: dry eye syndromes, interleukin-23, conjunctiva, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):10. https://doi.org/10.1167/iovs.66.2.10

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

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Yanjing Huang; Chengjie He; Qiuling Hu; Zhong Liu; Xingyi Li; Wuyou Gao; Xuanwei Liang; Rongxin Chen; Zhen Mao; Xianchai Lin
TAGS: basal cell carcinoma, eyelid, genes, infiltrative basal cell carcinoma, metabolites, neoplasms, metabolic disturbance, tumor microenvironment, up-regulation (physiology), spectrometry, mass, matrix-assisted laser desorption-ionization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):11. https://doi.org/10.1167/iovs.66.1.11

Includes: Supplemental Content

Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2024

Impact of Astigmatism on Axial Elongation in School-Age Children: A Five-Year Population-Based Study in Tianjin, China

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Dong Liang; Bei Du; Tsz-Wing Leung; Zhuzhu Liu; Qiang Su; Nan Jin; Ziyu Zhang; Mingguang He; Hua Yan; Ruihua Wei; Chea-Su Kee
TAGS: astigmatism, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):45. https://doi.org/10.1167/iovs.65.13.45

Includes: Supplemental Content

Genetics November 2024

Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort

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Yufei Xu; Xiao Liu; Nan Wu; Yanling Long; Jiayun Ren; Yu Wang; Xinyi Su; Zengping Liu; Yu Fujinami-Yokokawa; Kaoru Fujinami; Fang Chen; Xiaohong Meng; Yong Liu
TAGS: cohort studies, crystal structure, disease progression, eye, fovea centralis, longitudinal studies, genotype, vision, blindness, mutation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):27. https://doi.org/10.1167/iovs.65.13.27

Includes: Supplemental Content

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Retinal Cell Biology October 2024

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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Mei-Ling Gao; Tong-Yu Wang; Xin Lin; Chun Tang; Mengyao Li; Zhan-Pei Bai; Zhi-Cong Liu; Li-Jun Chen; Qing-Ran Kong; Shao-Hui Pan; Shan-Shan Zeng; Ya Guo; Jian-Qi Cai; Xiu-Feng Huang; Jun Zhang
TAGS: foreign medical graduates, microglia, organoids, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):19. https://doi.org/10.1167/iovs.65.12.19

Includes: Supplemental Content

Cornea September 2024

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng
TAGS: cornea, corneal epithelium, genes, macaca fascicularis, wound healing, epithelium, transcription, genetic, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):43. https://doi.org/10.1167/iovs.65.11.43

Includes: Supplemental Content

Cornea & External Disease September 2024

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

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Shi-Nan Wu; Xiao-Dong Chen; Qing-He Zhang; Yu-Qian Wang; Dan Yan; Chang-Sheng Xu; Shao-Pan Wang; Linfangzi Zhu; Dan-Yi Qin; Shu-Jia Guo; Lin Chen; Yu-Wen Liu; Caihong Huang; Jiaoyue Hu; Zuguo Liu
TAGS: keratitis, united states food and drug administration, incident reporting
Trans. Vis. Sci. Tech.. 2024; 13(9):17. https://doi.org/10.1167/tvst.13.9.17

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

Drawn correlations consistent with underestimation of perceived correlations from scatterplots

Lucy Cui; Medha Kini; Zili Liu

Journal of Vision. 2024; 24(10):781. https://doi.org/10.1167/jov.24.10.781

Retina September 2024

Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank

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Yiyuan Ma; Yue Wu; Ling Jin; Leyi Hu; Wen Chen; Charlotte Aimee Young; Xinyu Zhang; Danying Zheng; Zhenzhen Liu; Guangming Jin
TAGS: high density lipoprotein cholesterol, retinal nerve fiber layer, uk biobank
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):12. https://doi.org/10.1167/iovs.65.11.12

Includes: Supplemental Content

Methods August 2024

Genetic Influence of Oily Fish Intake on Age-Related Macular Degeneration Risk: A Two-Sample Mendelian Randomization Analysis

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Miaoran Gao; Jian Zhou; Jingru Zhao; Zihao Liu; Xianke Luo; Changlu Yang; Xinning Yu; Mengdan Tang; Jiamei Zhu; Xiaoling Yan
TAGS: age-related macular degeneration, fatty fish, genetics, mendelian randomization analysis, instrumental variables
Trans. Vis. Sci. Tech.. 2024; 13(8):14. https://doi.org/10.1167/tvst.13.8.14

Includes: Supplemental Content

Physiology and Pharmacology August 2024

Iron Chelator Deferiprone Restores Iron Homeostasis and Inhibits Retinal Neovascularization in Experimental Neovascular Age-Related Macular Degeneration

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Yuan Xu; Shiya Huang; Shengmei Zhou; Xin Wang; Mingyan Wei; Xiaodong Chen; Rongrong Zong; Xiang Lin; Shiying Li; Zuguo Liu; Qian Chen
TAGS: deferiprone, exudative age-related macular degeneration, iron, iron chelating agents, iron homeostasis, mice, retina, retinal neovascularization, very low density lipoprotein receptor
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):5. https://doi.org/10.1167/iovs.65.10.5

Includes: Supplemental Content

Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

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Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

ARVO Annual Meeting Abstract June 2024

Metabolomic Profiling of the Aqueous Humor in Patients with Congenital Cataract

Yinglin Yu; Hui Chen; Zhenzhen Liu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6159.

ARVO Annual Meeting Abstract June 2024

Unveiling the Culprit: The Crucial Role of Amacrine Cells in Optic Nerve Injury

Yiqing Li; Zhe Liu; Qi Zhang; Yehong Zhuo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):945.

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Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

Impact of Astigmatism on Axial Elongation in School-Age Children: A Five-Year Population-Based Study in Tianjin, China

Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

Drawn correlations consistent with underestimation of perceived correlations from scatterplots

Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank

Genetic Influence of Oily Fish Intake on Age-Related Macular Degeneration Risk: A Two-Sample Mendelian Randomization Analysis

Iron Chelator Deferiprone Restores Iron Homeostasis and Inhibits Retinal Neovascularization in Experimental Neovascular Age-Related Macular Degeneration

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

Metabolomic Profiling of the Aqueous Humor in Patients with Congenital Cataract

Unveiling the Culprit: The Crucial Role of Amacrine Cells in Optic Nerve Injury

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