Biochemistry and Molecular Biology

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Retinal Cell Biology July 2019

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

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Yi Liao; Houjian Zhang; Danxue He; Yan Wang; Binxiang Cai; Jingmeng Chen; Jianxing Ma; Zuguo Liu; Yalin Wu
TAGS: caspase-1, inflammasomes, nlr family, pyrin domain-containing 3 protein, retinal pigment epithelium, cell death, interleukin-18
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3034-3045. doi: 10.1167/iovs.18-26360

Includes: Supplemental Content

Cornea July 2019

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

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Aurelie Dos Santos; Alis Balayan; Martha L. Funderburgh; John Ngo; James L. Funderburgh; Sophie X. Deng
TAGS: keratocytes, stem cell, mesenchymal, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3013-3023. doi: 10.1167/iovs.19-27008

Includes: Supplemental Content

Articles July 2019

Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape

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Henry B. Wallace; James McKelvie; Colin R. Green; Stuti L. Misra
TAGS: cornea, visual accommodation, biomechanics, shape
Trans. Vis. Sci. Tech.. 2019; 8(4):5. doi: 10.1167/tvst.8.4.5

Biochemistry and Molecular Biology July 2019

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

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Feng He; Ralph M. Nichols; Lavanya Kailasam; Theodore G. Wensel; Melina A. Agosto
TAGS: biopharmaceutics classification system, phosphatidylinositols, phosphotransferases, retinal bipolar cells, tissue degeneration, mice, tissue membrane, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2861-2874. doi: 10.1167/iovs.19-26586

Includes: Supplemental Content

Articles June 2019

Age-Related Loss of Human Vitreal Viscoelasticity

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André Schulz; Silke Wahl; Annekatrin Rickmann; Jannine Ludwig; Boris V. Stanzel; Hagen von Briesen; Peter Szurman
TAGS: viscoelasticity, vitreous body
Trans. Vis. Sci. Tech.. 2019; 8(3):56. doi: 10.1167/tvst.8.3.56

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Retina June 2019

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

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Matthew M. Harper; Adam Hedberg-Buenz; Judith Herlein; Eric E. Abrahamson; Michael G. Anderson; Markus H. Kuehn; Randy H. Kardon; Pieter Poolman; Milos D. Ikonomovic
TAGS: alzheimer's disease, amyloidosis, basic local alignment search tool, mice, nerve degeneration, traumatic brain injuries, optic nerve, brain, retina, blast injuries, pupil light reflex
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2716-2725. doi: 10.1167/iovs.18-26353

Biochemistry and Molecular Biology June 2019

Modulation of cPKCγ on Synapsin-Ia/b–Specific Phosphorylation Sites in the Developing Visual Cortex of Mice

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Tao Fu; Jing Wang; Yichao Ding; Yunxia Zhang; Song Han; Junfa Li
TAGS: mice, synapsins, visual cortex, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2676-2684. doi: 10.1167/iovs.19-26675

Retina June 2019

Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

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Yousif Subhi; Marie Krogh Nielsen; Christopher Rue Molbech; Akio Oishi; Amardeep Singh; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: cytokine, exudative age-related macular degeneration, helper-inducer t-lymphocytes, interleukin-33, phenotype, plasma, polypoidal choroidal vasculopathy, regulatory t-lymphocytes, flow cytometry, immunology, interleukin-4
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2583-2590. doi: 10.1167/iovs.19-26882

Includes: Supplemental Content

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria, organelles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. doi: 10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics, clinical trial protocol document, body temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: 10.1167/tvst.8.3.40

Glaucoma June 2019

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

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Judith Kouassi Nzoughet; Juan Manuel Chao de la Barca; Khadidja Guehlouz; Stéphanie Leruez; Laurent Coulbault; Stéphane Allouche; Cinzia Bocca; Jeanne Muller; Patrizia Amati-Bonneau; Philippe Gohier; Dominique Bonneau; Gilles Simard; Dan Milea; Guy Lenaers; Vincent Procaccio; Pascal Reynier
TAGS: cohort studies, glaucoma, niacinamide, open-angle glaucoma, pellagra, plasma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2509-2514. doi: 10.1167/iovs.19-27099

Article June 2019

Switch rates for orthogonally oriented kinetic-depth displays are correlated across observers

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Alexander Pastukhov; Philipp Kastrup; Isabel Friederike Abs; Claus-Christian Carbon
TAGS: carbon, kinetics
Journal of Vision. 2019; 19(6):1. doi: 10.1167/19.6.1

Includes: Multimedia, Supplemental Content

Articles May 2019

Extracellular Matrix Protein Coating of Processed Fish Scales Improves Human Corneal Endothelial Cell Adhesion and Proliferation

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Yi-Jen Hsueh; David Hui-Kang Ma; Kathleen Sheng-Chuan Ma; Tze-Kai Wang; Cheng-Hung Chou; Chien-Cheng Lin; Min-Chang Huang; Li-Jyuan Luo; Jui-Yang Lai; Hung-Chi Chen
TAGS: cell proliferation, endothelial cells, extracellular matrix proteins, adhesions, cornea, proteins, weight measurement scales
Trans. Vis. Sci. Tech.. 2019; 8(3):27. doi: 10.1167/tvst.8.3.27

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2019

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice

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William P. Miller; Allyson L. Toro; Alistair J. Barber; Michael D. Dennis
TAGS: oxidative stress, diabetes mellitus, hyperglycemia, glucose, cell death, feedback, mice, proteins, retina, glycogen synthase kinase 3, proto-oncogene proteins c-akt, hyperglycemic agents
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2369-2379. doi: 10.1167/iovs.19-26606

Physiology and Pharmacology May 2019

Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH

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Oleg Yarishkin; Tam T. T. Phuong; David Križaj
TAGS: membrane potentials, protons, trabecular meshwork, eye, quinine, alkalinization, mechanotransduction, cellular, synthetic cannabinoids
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2294-2303. doi: 10.1167/iovs.19-26851

Includes: Supplemental Content

Cornea May 2019

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

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Kyu-Yeon Han; Jin-Hong Chang; Dimitri T. Azar
TAGS: endothelial cells, proteins, exosomes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2321-2329. doi: 10.1167/iovs.18-26277

Cornea May 2019

Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction

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Douglas Borchman; Aparna Ramasubramanian; Gary N. Foulks
TAGS: cohort studies, dry eye syndromes, esters, meibomian gland, lipids, molar tooth, vibration, pathophysiology, donors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2286-2293. doi: 10.1167/iovs.19-26812

Retina May 2019

Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling, Mediates Rod Photoreceptor Axonal Retraction After Retinal Injury

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Weiwei Wang; Eva Halasz; Ellen Townes-Anderson
TAGS: actins, presynaptic terminals, signal transduction, axon, microfilaments, phosphorylation, retinal detachment, rhoa gtp-binding protein, rod photoreceptors, wounds and injuries, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2274-2285. doi: 10.1167/iovs.18-26077

Glaucoma May 2019

Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure

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Yuchen Fan; Li Guo; Jiahong Wei; Junzhao Chen; Hao Sun; Tao Guo
TAGS: extracellular matrix, ocular hypertension, body tissue, trabecular meshwork, intraocular pressure, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2072-2082. doi: 10.1167/iovs.19-26585

Includes: Supplemental Content

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Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

Age-Related Loss of Human Vitreal Viscoelasticity

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

Modulation of cPKCγ on Synapsin-Ia/b–Specific Phosphorylation Sites in the Developing Visual Cortex of Mice

Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

Switch rates for orthogonally oriented kinetic-depth displays are correlated across observers

Extracellular Matrix Protein Coating of Processed Fish Scales Improves Human Corneal Endothelial Cell Adhesion and Proliferation

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice

Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction

Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling, Mediates Rod Photoreceptor Axonal Retraction After Retinal Injury

Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure

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