Biochemistry and Molecular Biology

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Retinal Cell Biology September 2018

AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

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Yonju Ha; Wei Liu; Hua Liu; Shuang Zhu; Fan Xia; Julia E. Gerson; Nisha A. Azhar; Ronald G. Tilton; Massoud Motamedi; Rakez Kayed; Wenbo Zhang
TAGS: immunohistochemistry, tau proteins, wounds and injuries, mice, retina, stress, transfer technique, oligomers, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4670-4682. doi: 10.1167/iovs.18-24427

Includes: Supplemental Content

Retina September 2018

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

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Anri Nishinaka; Yuki Inoue; Shinichiro Fuma; Yoshifumi Hida; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara
TAGS: vascular endothelial growth factor a, edema, injections, lasers, retinal vein occlusion, antibodies, eye, mice, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4701-4713. doi: 10.1167/iovs.18-23994

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2018

Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs

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Liqin Jiang; Sen Zhang; Rongfang Chen; Li Ma; Xiaojun Wang; Yingying Wen; Jia Qu; Xiangtian Zhou
TAGS: dopamine, caviidae, monophenol monooxygenase, refractive errors, eye, uvea, kojic acid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4631-4638. doi: 10.1167/iovs.17-22315

Glaucoma September 2018

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

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Bryn L. Brazile; Yi Hua; Ning-Jiun Jan; Jacob Wallace; Alexandra Gogola; Ian A. Sigal
TAGS: collagen, eye, cribriform plate
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4653-4661. doi: 10.1167/iovs.18-24763

Includes: Supplemental Content

Special Issue September 2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

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Imran A. Bhutto; Shuntaro Ogura; Rajkumar Baldeosingh; D. Scott McLeod; Gerard A. Lutty; Malia M. Edwards
TAGS: phenotype, atrophy, injections, photoreceptors, wounds and injuries, eye, chief complaint
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD143-AMD151. doi: 10.1167/iovs.18-24245

Includes: Supplemental Content

Article September 2018

Experience-dependent long-term facilitation of skew adaptation

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Selam W. Habtegiorgis; Katharina Rifai; Markus Lappe; Siegfried Wahl
TAGS: facilitation, perceptual aftereffect
Journal of Vision. 2018; 18(9):7. doi: 10.1167/18.9.7

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Biochemistry and Molecular Biology September 2018

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency

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Stéphanie Leruez; Alexandre Marill; Thomas Bresson; Grégoire de Saint Martin; Adrien Buisset; Jeanne Muller; Lydie Tessier; Cédric Gadras; Christophe Verny; Philippe Gohier; Patrizia Amati-Bonneau; Guy Lenaers; Dominique Bonneau; Gilles Simard; Dan Milea; Vincent Procaccio; Pascal Reynier; Juan Manuel Chao de la Barca
TAGS: aging, mitochondria, glaucoma, open-angle glaucoma, polyamines, pathophysiology, elderly, metabolites, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4355-4361. doi: 10.1167/iovs.18-24938

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2018

Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs

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Sen Zhang; Jinglei Yang; Peter S. Reinach; Fengjiao Wang; Lishuai Zhang; Miaomiao Fan; Huangfang Ying; Miaozhen Pan; Jia Qu; Xiangtian Zhou
TAGS: 3,4-dihydroxyphenylacetic acid, caviidae, myopia, quinpirole, dopamine receptors, refractive errors, sk&f-38393, sulpiride, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4441-4448. doi: 10.1167/iovs.17-21574

Includes: Supplemental Content

Review September 2018

A two-level hierarchical framework of visual short-term memory

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Tal Yatziv; Yoav Kessler
TAGS: attention, color, ion channel gating, memory, precision, visual working memory
Journal of Vision. 2018; 18(9):2. doi: 10.1167/18.9.2

Articles August 2018

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules

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Nobuo Machinaga; Gary W. Ashley; Ralph Reid; Atsushi Yamasaki; Kyosuke Tanaka; Koichi Nakamura; Yoshiyuki Yabe; Yasushi Yoshigae; Daniel V. Santi
TAGS: half-life, injections, oryctolagus cuniculus, vitreous body, eye, molecule
Trans. Vis. Sci. Tech.. 2018; 7(4):21. doi: 10.1167/tvst.7.4.21

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

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Nethrajeith Srinivasalu; Chanyi Lu; Miaozhen Pan; Peter Sol Reinach; Yingying Wen; Yang Hu; Jia Qu; Xiangtian Zhou
TAGS: gene expression, collagen, genes, caviidae, myopia, cyclic amp, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4318-4325. doi: 10.1167/iovs.17-224685

Includes: Supplemental Content

Article August 2018

Sensory and decision-making processes underlying perceptual adaptation

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Nathan Witthoft; Long Sha; Jonathan Winawer; Roozbeh Kiani
TAGS: diffusion, decision making, facial expression, happiness, judgment, psychometrics, reaction time
Journal of Vision. 2018; 18(8):10. doi: 10.1167/18.8.10

Includes: Supplemental Content

Article August 2018

Slow gain fluctuations limit benefits of temporal integration in visual cortex

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Robbe L. T. Goris; Corey M. Ziemba; J. Anthony Movshon; Eero P. Simoncelli
TAGS: neurons, visual cortex, reliability, heterogeneity of variance, primary visual cortex
Journal of Vision. 2018; 18(8):8. doi: 10.1167/18.8.8

Cornea August 2018

Differential Distribution of Laminin N-Terminus α31 Across the Ocular Surface: Implications for Corneal Wound Repair

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Valentina Barrera; Lee D. Troughton; Valentina Iorio; Siyin Liu; Olutobi Oyewole; Carl M. Sheridan; Kevin J. Hamill
TAGS: immunohistochemistry, epithelium, homeostasis, laminin, wound healing, antibodies, cornea, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4082-4093. doi: 10.1167/iovs.18-24037

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

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Na Wang; Chen Zou; Shuzhi Zhao; Yunzhi Wang; Changjing Han; Zhi Zheng
TAGS: apoptosis, diabetes mellitus, inflammation, glucose, diabetic retinopathy, rats, angptl3 gene, fenofibrate, integrins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4210-4217. doi: 10.1167/iovs.18-24155

Genetics August 2018

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
TAGS: meta-analysis, esotropia, cohort studies, disease susceptibility, genome, parent, single nucleotide polymorphism, strabismus, genetics, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4054-4064. doi: 10.1167/iovs.18-24082

Includes: Supplemental Content

Cornea August 2018

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

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Joanna S. Saade; Chao Xing; Xin Gong; Zhengyang Zhou; V. Vinod Mootha
TAGS: alleles, child, hereditary corneal dystrophy, endothelium, parent, trinucleotide repeats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4065-4070. doi: 10.1167/iovs.18-24119

Includes: Supplemental Content

Retinal Cell Biology August 2018

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

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Joshua A. Chu-Tan; Matt Rutar; Kartik Saxena; Riemke Aggio-Bruce; Rohan W. Essex; Krisztina Valter; Haihan Jiao; Nilisha Fernando; Yvette Wooff; Michele C. Madigan; Jan Provis; Riccardo Natoli
TAGS: monocyte chemoattractant protein-1, photoreceptors, retinal degeneration, retinitis, retina, micrornas
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4094-4105. doi: 10.1167/iovs.18-24623

Includes: Supplemental Content

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AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Experience-dependent long-term facilitation of skew adaptation

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency

Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs

A two-level hierarchical framework of visual short-term memory

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

Sensory and decision-making processes underlying perceptual adaptation

Slow gain fluctuations limit benefits of temporal integration in visual cortex

Differential Distribution of Laminin N-Terminus α31 Across the Ocular Surface: Implications for Corneal Wound Repair

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

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