Biochemistry and Molecular Biology

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Biochemistry and Molecular Biology January 2019

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

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Saima Limi; Yilin Zhao; Peng Guo; Melissa Lopez-Jones; Deyou Zheng; Robert H. Singer; Arthur I. Skoultchi; Ales Cvekl
TAGS: crystallins, lens, crystalline, lens (device), rna, messenger, mice, rna, genes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):234-244. doi: 10.1167/iovs.18-25921

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Retina January 2019

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

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Marie Krogh Nielsen; Yousif Subhi; Christopher Rue Molbech; Mads Krüger Falk; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: inflammation, atrophy, plasma, c-reactive protein, interleukin-6, age-related macular degeneration, atrophic condition of skin, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):202-208. doi: 10.1167/iovs.18-25878

Includes: Supplemental Content

Visual Neuroscience January 2019

Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection

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Stephanie N. Blandford; Michele L. Hooper; Takeshi Yabana; Balwantray C. Chauhan; William H. Baldridge; Spring R. M. Farrell
TAGS: calcium, diagnostic imaging, optic nerve, retina, mice, transgenic, fluorescence, immunohistochemistry, khat
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):183-191. doi: 10.1167/iovs.18-25861

Includes: Supplemental Content

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

Visual Neuroscience January 2019

Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram

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J. Jason McAnany; Jason C. Park
TAGS: photopsia, diabetic retinopathy, diabetes mellitus, pathophysiology, phototransduction, electroretinography, retinal cone, nonproliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):64-72. doi: 10.1167/iovs.18-25946

Article January 2019

The separable effects of feature precision and item load in visual short-term memory

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Simon D. Lilburn; Philip L. Smith; David K. Sewell
TAGS: sample size, diffusion, memory, visual working memory, precision
Journal of Vision. 2019; 19(1):2. doi: 10.1167/19.1.2

Articles January 2019

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

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Joseph D. Bogaard; Jonathon B. Young; Asad Movahedan; Iris S. Kassem
TAGS: enoxaparin, child, animal model, triamcinolone, eye, fibrin, therapeutic intervention, oryctolagus cuniculus, postoperative care, anterior chamber of eye, inflammation, enzyme-linked immunosorbent assay, did not receive therapy or drug
Trans. Vis. Sci. Tech.. 2019; 8(1):5. doi: 10.1167/tvst.8.1.5

Lens January 2019

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

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Laura Wernecke; Susanne Keckeis; Nadine Reichhart; Olaf Strauß; Daniel J. Salchow
TAGS: epithelium, cataract, child, pediatrics, lens epithelial cell, patient characteristics, rna, messenger, cell transdifferentiation
Invest. Ophthalmol. Vis. Sci.. 2019; 59(15):5785-5794. doi: 10.1167/iovs.18-23789

Includes: Supplemental Content

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: mice, retinal cone, mutation, electroretinography, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. doi: 10.1167/iovs.18-24328

Articles December 2018

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

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Peng Xu; Chifune Kai; Satoshi Kawasaki; Yuki Kobayashi; Kouji Yamamoto; Motokazu Tsujikawa; Ryuhei Hayashi; Kohji Nishida
TAGS: proteins, epcam gene, corneal epithelial cells, antibodies, epithelial cell adhesion molecule, genes, epithelium, cornea
Trans. Vis. Sci. Tech.. 2018; 7(6):30. doi: 10.1167/tvst.7.6.30

Immunology and Microbiology December 2018

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

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Aihua Tang; Armando R. Caballero; Mary E. Marquart; Michael A. Bierdeman; Richard J. O'Callaghan
TAGS: pseudomonas aeruginosa, mutation, catalysis, cornea, serine proteases, virulence factors, proteolytic enzymes, proteins, endopeptidases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5993-6002. doi: 10.1167/iovs.18-25834

Biochemistry and Molecular Biology December 2018

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

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Catherine J. Choi; Wensi Tao; Ravi Doddapaneni; Zenith Acosta-Torres; Nathan W. Blessing; Bradford W. Lee; Daniel Pelaez; Sara T. Wester
TAGS: prostaglandins, synthetic, bimatoprost
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5912-5923. doi: 10.1167/iovs.18-25134

Article December 2018

Insufficient compensation for self-motion during perception of object speed: The vestibular Aubert-Fleischl phenomenon

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Isabelle T. Garzorz; Tom C. A. Freeman; Marc O. Ernst; Paul R. MacNeilage
TAGS: motion, perception
Journal of Vision. 2018; 18(13):9. doi: 10.1167/18.13.9

Glaucoma December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

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Emily Mathieu; Neeru Gupta; Luz A. Paczka-Giorgi; Xun Zhou; Amir Ahari; Rafael Lani; Joseph Hanna; Yeni H. Yücel
TAGS: glaucoma, cerebrospinal fluid, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5876-5884. doi: 10.1167/iovs.18-24521

Biochemistry and Molecular Biology December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

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Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
TAGS: mutation, corneal diseases, electroretinography, keratoconus, luciferases, missense mutation, cornea, diagnostic imaging, mice, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5824-5835. doi: 10.1167/iovs.18-25490

Includes: Supplemental Content

Articles December 2018

Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications

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Sascha Dammeier; Peter Martus; Franziska Klose; Michael Seid; Dario Bosch; Janina D‘Alvise; Focke Ziemssen; Spyridon Dimopoulos; Marius Ueffing
TAGS: eye, proteins, metabolites
Trans. Vis. Sci. Tech.. 2018; 7(6):22. doi: 10.1167/tvst.7.6.22

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

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Miaozhen Pan; Shiming Jiao; Peter S. Reinach; Jiaofeng Yan; Yanan Yang; Qihang Li; Nethrajeith Srinivasalu; Jia Qu; Xiangtian Zhou
TAGS: bezafibrate, caviidae, injections, myopia, apolipoprotein a-ii, eye, ppar alpha
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5803-5815. doi: 10.1167/iovs.17-22297

Includes: Supplemental Content

Retinal Cell Biology November 2018

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

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Shengxu Liu; Bingbing Xie; Xiaojing Song; Dandan Zheng; Liwen He; Guilan Li; Guanjie Gao; Fuhua Peng; Minzhong Yu; Jian Ge; Xiufeng Zhong
TAGS: retinal pigment cell, spheroids, cellular, organoids
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5659-5669. doi: 10.1167/iovs.17-23613

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

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Joost Brinks; Elon H. C. van Dijk; Mahmoud Habeeb; Aikaterini Nikolaou; Roula Tsonaka; Hendrika A. B. Peters; Hetty C. M. Sips; Arjanneke F. van de Merbel; Eiko K. de Jong; Robbert G. E. Notenboom; Szymon M. Kielbasa; Silvère M. van der Maarel; Paul H. A. Quax; Onno C. Meijer; Camiel J. F. Boon
TAGS: hydrocortisone, endothelial cells, adrenal corticosteroids, glucocorticoids, patient isolation, mineralocorticoids, agonists, antagonists, central serous chorioretinopathy, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5682-5692. doi: 10.1167/iovs.18-25054

Includes: Supplemental Content

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Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram

The separable effects of feature precision and item load in visual short-term memory

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

Insufficient compensation for self-motion during perception of object speed: The vestibular Aubert-Fleischl phenomenon

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

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