Biochemistry and Molecular Biology

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Articles June 2021

Growth Modeling for Quantitative, Spatially Resolved Geographic Atrophy Lesion Kinetics

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Eric M. Moult; Yunchan Hwang; Yingying Shi; Liang Wang; Siyu Chen; Nadia K. Waheed; Giovanni Gregori; Philip J. Rosenfeld; James G. Fujimoto
TAGS: atrophy, eye, growth rate, kinetics
Trans. Vis. Sci. Tech.. 2021; 10(7):26. doi: https://doi.org/10.1167/tvst.10.7.26

Includes: Supplemental Content

Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. doi: https://doi.org/10.1167/iovs.62.7.21

Visual Neuroscience June 2021

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi
TAGS: actins, rats, visual acuity, visual cortex, mitochondria, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):20. doi: https://doi.org/10.1167/iovs.62.7.20

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. doi: https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

Cornea June 2021

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
TAGS: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride, stress, mosmol, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):11. doi: https://doi.org/10.1167/iovs.62.7.11

Includes: Supplemental Content

Articles June 2021

ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina

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Kevin J. Cao; John H. Kim; Heike Kroeger; Patricia M. Gaffney; Jonathan H. Lin; Christina J. Sigurdson; Jerry Yang
TAGS: amyloid, fluorescence, mice, retina, diagnostic imaging, eye, body tissue
Trans. Vis. Sci. Tech.. 2021; 10(7):5. doi: https://doi.org/10.1167/tvst.10.7.5

Includes: Supplemental Content

Retinal Cell Biology June 2021

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice, stress, ischemia, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):5. doi: https://doi.org/10.1167/iovs.62.7.5

Methods May 2021

Establishment and Characterization of a Novel Human Ocular Adnexal Sebaceous Carcinoma Cell Line

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Andrew J. Rong; Ryan A. Gallo; Michelle G. Zhang; Ravi Doddapaneni; Anthony J. Griswold; John Y. Lee; Stefan Kurtenbach; Sander R. Dubovy; David T. Tse; Daniel Pelaez
TAGS: cell lines, neoplasms, sebaceous adenocarcinoma, drug screening
Trans. Vis. Sci. Tech.. 2021; 10(6):34. doi: https://doi.org/10.1167/tvst.10.6.34

Includes: Supplemental Content

Articles May 2021

Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines

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Wenyan Wang; Yongzhen Miao; Shangru Sui; Yanan Wang; Shen Wu; Qilong Cao; Haoyun Duan; Xia Qi; Qingjun Zhou; Xiaojing Pan; Jingxue Zhang; Xuehong Chen; Yantao Han; Ningli Wang; Markus H. Kuehn; Wei Zhu
TAGS: cytokine, culture media, conditioned, reverse transcriptase polymerase chain reaction
Trans. Vis. Sci. Tech.. 2021; 10(6):27. doi: https://doi.org/10.1167/tvst.10.6.27

Includes: Supplemental Content

Retina May 2021

The Predictive Role of Thyroid Hormone Levels for Early Diabetic Retinal Changes in Experimental Rat and Human Diabetes

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Anna Énzsöly; Rozina I. Hajdú; Zsolt Turóczi; Irén Szalai; Erika Tátrai; Fanni Pálya; Zoltán Z. Nagy; Csaba Mátyás; Attila Oláh; Tamás Radovits; Klaudia Szabó; Bulcsú Dékány; Arnold Szabó; Ákos Kusnyerik; Petra Soltész; Dániel S. Veres; Anikó Somogyi; Gábor M. Somfai; Ákos Lukáts
TAGS: diabetes mellitus, thyroid hormones, retinal cone, retina, opsin
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):20. doi: https://doi.org/10.1167/iovs.62.6.20

Cornea May 2021

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

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James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman
TAGS: epithelium, keratoconus, wnt10a gene, bowman's layer
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):16. doi: https://doi.org/10.1167/iovs.62.6.16

Includes: Supplemental Content

Article May 2021

Amodal completion instead of predictive coding can explain activity suppression of early visual cortex during illusory shape perception

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Chuyao Yan; Alexis Pérez-Bellido; Floris P. de Lange
TAGS: form perception, functional magnetic resonance imaging, illusions, primary visual cortex, visual cortex, down-regulation, shape, perception
Journal of Vision. 2021; 21(5):13. doi: https://doi.org/10.1167/jov.21.5.13

Includes: Multimedia, Supplemental Content

Glaucoma May 2021

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells

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Bindu Kodati; Dorota L. Stankowska; Vignesh R. Krishnamoorthy; Raghu R. Krishnamoorthy
TAGS: endothelin-1, glaucoma, mice, nerve degeneration, neuroprotection, phosphotransferases, retinal ganglion cells, immunohistochemistry, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):13. doi: https://doi.org/10.1167/iovs.62.6.13

Biochemistry and Molecular Biology May 2021

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

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Salut Alba-Arbalat; Magi Andorra; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Marina Dotti-Boada; Irene Pulido-Valdeolivas; Sara Llufriu; Yolanda Blanco; Maria Sepulveda; Albert Saiz; Oscar Batet; Iker Bilbao; Iratxe Torre; Ivan Amat-Roldan; Elena H. Martinez-Lapiscina; Pablo Villoslada
TAGS: molecule, multiple sclerosis, retina, spectrum analysis, raman
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):11. doi: https://doi.org/10.1167/iovs.62.6.11

Includes: Supplemental Content

Cornea May 2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

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Chenyang Dai; Rao Me; Nan Gao; Guanyu Su; Xinyi Wu; Fu-Shin X. Yu
TAGS: cornea, keratitis, mice, signal transduction, fungal keratitis, cytokine, infections, candida albicans, interleukin-33
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):10. doi: https://doi.org/10.1167/iovs.62.6.10

Review May 2021

Metabolomics in Glaucoma: A Systematic Review

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Ying Wang; Xiao-Wen Hou; Gang Liang; Chen-Wei Pan
TAGS: glaucoma, metabolomics, metabolites, systematic reviews, biological markers
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):9. doi: https://doi.org/10.1167/iovs.62.6.9

Includes: Supplemental Content

Articles May 2021

Comprehensive Proteomic Profiling of Aqueous Humor Proteins in Proliferative Diabetic Retinopathy

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Hu Xiao; Wen Xin; Li Mei Sun; Song Shan Li; Ting Zhang; Xiao Yan Ding
TAGS: hypertension, proliferative diabetic retinopathy, proteins, aqueous humor
Trans. Vis. Sci. Tech.. 2021; 10(6):3. doi: https://doi.org/10.1167/tvst.10.6.3

Biochemistry and Molecular Biology May 2021

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1

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Xiaoyue Deng; Toshiro Iwagawa; Masaya Fukushima; Yutaka Suzuki; Sumiko Watanabe
TAGS: apoptosis, histones, plasmids, retina, rna-seq, mice, immunohistochemistry, antibodies
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):1. doi: https://doi.org/10.1167/iovs.62.6.1

Includes: Supplemental Content

Letters to the Editor April 2021

Author Response: Surface Area of the Exposed Eye

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Ben J. Glasgow
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):19. doi: https://doi.org/10.1167/iovs.62.4.19

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

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Growth Modeling for Quantitative, Spatially Resolved Geographic Atrophy Lesion Kinetics

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

Establishment and Characterization of a Novel Human Ocular Adnexal Sebaceous Carcinoma Cell Line

Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines

The Predictive Role of Thyroid Hormone Levels for Early Diabetic Retinal Changes in Experimental Rat and Human Diabetes

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

Amodal completion instead of predictive coding can explain activity suppression of early visual cortex during illusory shape perception

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

Metabolomics in Glaucoma: A Systematic Review

Comprehensive Proteomic Profiling of Aqueous Humor Proteins in Proliferative Diabetic Retinopathy

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1

Author Response: Surface Area of the Exposed Eye

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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