Clinical and Epidemiologic Research

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Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

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Allie Lee; Dennis T. W. Law; Alex H. S. Kan; Flores F. P. Cruz; Vishal Jhanji; Hunter K. L. Yuen; Michael Y. Ni
TAGS: chinese (other dialects), eye, eye cancer, eyelid neoplasms, hong kong, lymphoma, chinese people, epidemiology, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):15. https://doi.org/10.1167/iovs.66.3.15

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

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Alexis O'Neil; Roshan A. Welikala; Sarah Barman; Christopher G. Owen; Alicja R. Rudnicka; Mohan Rakesh; Marie-Hélène Roy-Gagnon; David Maberley; Ellen E. Freeman
TAGS: aging, longitudinal studies, retinal vessels, obesity, diabetes mellitus, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):13. https://doi.org/10.1167/iovs.66.3.13

Cornea February 2025

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

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Ramaraj Kannan; Rohit Shetty; Trailokyanath Panigrahi; Siew Kwan Koh; Pooja Khamar; Vrushali Deshpande; Rudy M. M. A. Nuijts; Marlies Gijs; Krishnatej Nishtala; Lei Zhou; Arkasubhra Ghosh
TAGS: proteins, cohort studies, keratoconus, proteomics, signal transduction, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):60. https://doi.org/10.1167/iovs.66.2.60

Includes: Supplemental Content

Retina February 2025

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

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Gilad Allon; Siying Lin; Anthony G. Robson; Gavin Arno; Magella M. Neveu; Pirro G. Hysi; Michel Michaelides; Andrew R. Webster; Omar A. Mahroo
TAGS: cohort studies, diagnostic imaging, genetics, retinal diseases, visual acuity, electrophysiology, family, eye, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):50. https://doi.org/10.1167/iovs.66.2.50

Clinical and Epidemiologic Research February 2025

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

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Qiuxuan Du; Ying Zhang; Yusen Huang
TAGS: cataract, cataract, childhood, chinese (other dialects), chinese people, eye, growth rate, intraocular lens implantation procedure, multifocal intraocular lenses, refraction, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):33. https://doi.org/10.1167/iovs.66.2.33

Retina February 2025

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

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Ziqi Tang; Dawei Yang; Truong X. Nguyen; Shuyi Zhang; Danqi Fang; Victor T. T. Chan; Clement C. Tham; Elliott H. Sohn; Ken K. Tsang; Cherie Y. K. Wong; Vivian W. K. Hui; Amy H. Y. Yu; Julia T. W. Lam; Carmen K. M. Chan; Timothy Y. Y. Lai; Simon K. H. Szeto; Carol Y. Cheung
TAGS: cohort studies, diabetes mellitus, diabetic retinopathy, dorsal raphe nucleus, nerve degeneration, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):32. https://doi.org/10.1167/iovs.66.2.32

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Clinical and Epidemiologic Research February 2025

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

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Yihua Yue; Sangita P. Patel; Jing Nie; Chris A. Andrews; Jean Wactawski-Wende; Aladdin H. Shadyab; Robert Wallace; Amy E. Millen
TAGS: anthropometric measures, body mass index procedure, endothelium, hereditary corneal dystrophy, women's health initiative, obesity, significance, body weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):26. https://doi.org/10.1167/iovs.66.2.26

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Comprehensive Visualization of Choroidal Alterations in Thyroid Eye Disease With Ultra-Widefield OCT Angiography

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Yi Wang; Tengbo Rao; Jichao Zhou; Debo You; Jiarui Yang; Lingge Suo
TAGS: angiogram, eye, graves' ophthalmopathy, optic disk, cortical blindness, vascular flow, cardiovascular imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):25. https://doi.org/10.1167/iovs.66.2.25

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Single and Multiple Visual Function Impairments and Associated- Vision-Related Quality of Life Impact in Older Adults Aged 60 to 100 Years

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Preeti Gupta; Tai Anh Vu; Chiew Meng Johnny Wong; Sahil Thakur; Alex A. Black; Joanne M. Wood; Ryan E. K. Man; Eva K. Fenwick; Ecosse L. Lamoureux
TAGS: older adult, prevalence, quality of life, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):18. https://doi.org/10.1167/iovs.66.2.18

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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Jie Chen; Tianyu Zhu; Ziyue Huang; Renbing Jia; Shiqiong Xu
TAGS: cohort studies, eye, orbit evisceration, sebaceous adenocarcinoma, sebaceous adenocarcinoma of eyelid, neoplasm metastasis, surgical procedures, operative, recurrence, selenocysteine, cerebral arterial thrombosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):40. https://doi.org/10.1167/iovs.66.1.40

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Validating Rules for Defining No Improvement of Visual Acuity in Childhood Amblyopia

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Rui Wu; Ruth E. Manny; Jonathan M. Holmes; B. Michele Melia; Zhuokai Li; David K. Wallace; Eileen E. Birch; Raymond T. Kraker; Susan A. Cotter; on behalf of the Pediatric Eye Disease Investigator Group
TAGS: amblyopia, amblyopia, pediatric, visual acuity, false-negative results, false-positive results, visual analogue pain scale, eyeglasses, sensitivity analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):4. https://doi.org/10.1167/iovs.66.1.4

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

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Yanping Chen; Ruilin Xiong; Jian Zhang; Shaopeng Yang; Huangdong Li; Ziyu Zhu; Peiyuan Wang; Mingguang He; Yingfeng Zheng; Wei Wang
TAGS: adult, child, eye, incidence, myopia, vision, visual impairment, blindness, world health organization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):2. https://doi.org/10.1167/iovs.66.1.2

Includes: Supplemental Content

Retina December 2024

Patient-Reported Experience Measurements From Individuals With Inherited Retinal Disorders Involved in Observational Research

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Malena Daich Varela; Shaima Hashem; Dayyanah Sumodhee; Michel Michaelides
TAGS: observational studies, questionnaires, retinal diseases
Trans. Vis. Sci. Tech.. 2024; 13(12):9. https://doi.org/10.1167/tvst.13.12.9

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Natural Course of Refractive Error in Congenital Stationary Night Blindness: Implications for Myopia Treatment

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Mariëlle M. F. Poels; Gerard C. de Wit; Mieke M. C. Bijveld; Maria M. van Genderen
TAGS: myopia, night blindness, congenital stationary, refraction, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):9. https://doi.org/10.1167/iovs.65.14.9

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2024

Ranked Importance of Visual Function Outcome Measures in Choroideremia Clinical Trials

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Amandeep Singh Josan; Laura Jayne Taylor; Kanmin Xue; Jasmina Cehajic-Kapetanovic; Robert Edward MacLaren
TAGS: choroideremia, functional measures, outcome measures, vision
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):58. https://doi.org/10.1167/iovs.65.13.58

Includes: Supplemental Content

Retina November 2024

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

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Ricarda Jendritza; Krunoslav Stingl; Torsten Strasser; Ronja Jung; Felix Tonagel; Paul Richter; Anton Sonntag; Tobias Peters; Helmut Wilhelm; Barbara Wilhelm; Carina Kelbsch
TAGS: biological markers, cardiac progenitor cells, cohort studies, pupil, pupil light reflex, retinal cone, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):3. https://doi.org/10.1167/iovs.65.6.3

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Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

Comprehensive Visualization of Choroidal Alterations in Thyroid Eye Disease With Ultra-Widefield OCT Angiography

Single and Multiple Visual Function Impairments and Associated- Vision-Related Quality of Life Impact in Older Adults Aged 60 to 100 Years

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

Validating Rules for Defining No Improvement of Visual Acuity in Childhood Amblyopia

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

Patient-Reported Experience Measurements From Individuals With Inherited Retinal Disorders Involved in Observational Research

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Natural Course of Refractive Error in Congenital Stationary Night Blindness: Implications for Myopia Treatment

Ranked Importance of Visual Function Outcome Measures in Choroideremia Clinical Trials

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

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