Cornea

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Immunology and Microbiology July 2025

Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis

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Nan Gao; Rao Me; Sukhvinder Singh; Ashok Kumar; Fu-Shin X. Yu
TAGS: cornea, diabetes mellitus, hyperglycemia, infections, itaconate, keratitis, mice, osteogenesis imperfecta, oxygenation index measurement, deficiency, immune
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):51. https://doi.org/10.1167/iovs.66.9.51

Includes: Supplemental Content

Cornea July 2025

Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells

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Seung Hyeun Lee; Soo Jin Lee; Ahra Koh; Ki Hean Kim; Kyoung Woo Kim
TAGS: apoptotic cell clearance, cornea, macrophages, ultraviolet b radiation, apoptosis, keratitis, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):49. https://doi.org/10.1167/iovs.66.9.49

Includes: Supplemental Content

Glaucoma July 2025

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

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Victor A. de Vries; Anita Szabo; Joëlle E. Vergroesen; Siyin Liu; Karin A. van Garderen; Kirithika Muthusamy; Petra Liskova; Lubica Dudakova; Anthony P. Khawaja; Stephen J. Tuft; Caroline C. W. Klaver; Alice E. Davidson; Wishal D. Ramdas
TAGS: cardiac ct, cohort studies, cornea, glaucoma, mendelian randomization analysis, genetic risk score, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):22. https://doi.org/10.1167/iovs.66.9.22

Includes: Supplemental Content

Cornea July 2025

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

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Haoyu Li; Hanhan Peng; Benteng Ma; Xinyue Sun; Liwei Zhang; Baihua Chen
TAGS: cornea, diabetes mellitus, epithelium, hyperglycemia, oxidative stress, proteins, pten gene, wound healing, antioxidants, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):20. https://doi.org/10.1167/iovs.66.9.20

Includes: Supplemental Content

Cornea & External Disease July 2025

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

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Dan Wang; Yueni Ma; Mengyu Zhang; Fei Li; Ning Gao; Yuanyuan Qi; Zhenying Shang; Ruibo Yang
TAGS: autonomic dysfunction, depressive disorders, dry eye syndromes, pathogenesis, apoptosis, rats, bodily secretions, oxidative stress, sympathectomy
Trans. Vis. Sci. Tech.. 2025; 14(7):4. https://doi.org/10.1167/tvst.14.7.4

Includes: Supplemental Content

Cornea July 2025

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng
TAGS: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt, signal transduction, wound healing, wounds and injuries, cornea, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):2. https://doi.org/10.1167/iovs.66.9.2

Includes: Supplemental Content

Cornea & External Disease June 2025

In Vivo Stability of Electronic Intraocular Lens Implant for Corneal Blindness

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Ibraim V. Vieira; Victoria H. Fan; Michael W. Wiemer; Brian E. Lemoff; Kishan S. Sood; Maria Julia Mussa; Charles Q. Yu
TAGS: blindness, cornea, implants, intraocular lens implant device, eye, oryctolagus cuniculus, implantation procedure
Trans. Vis. Sci. Tech.. 2025; 14(6):33. https://doi.org/10.1167/tvst.14.6.33

Lens June 2025

Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children

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Na Li; Luodian Luobu; Bei Du; Weiping Lin; Ruihua Wei
TAGS: child, lens (device), lens, crystalline, myopia, orthokeratology contact lenses
Trans. Vis. Sci. Tech.. 2025; 14(6):27. https://doi.org/10.1167/tvst.14.6.27

Cornea June 2025

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

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Chia-Ying Tsai; Wei-Lun Huang; Shang-Chih Yang; Bo-Da Huang; Vladlen Klochkov; Shu-Lang Liao; Albert Y. Wu; Wei-Li Chen
TAGS: adrenal corticosteroids, blood platelets, cornea, epithelium, exposure keratoconjunctivitis, glucocorticoids, lysate, microscopy, confocal, mineralocorticoids, anti-inflammatory agents
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):73. https://doi.org/10.1167/iovs.66.6.73

Cornea June 2025

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

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Zhiwei Zha; Juan Li; Shuang Xie; Xunjie Shang; Zixin Xu; Haiyuan Chang; Kaisheng Wang; Yang Liu; Wei Chen
TAGS: dry eye syndromes, endoplasmic reticulum stress, fgf10 protein, human, mice, cornea, corneal epithelium, up-regulation (physiology), eye, body tissue, stress
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):72. https://doi.org/10.1167/iovs.66.6.72

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

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Nemanja Milićević; Cristina Sandu; Etienne Challet; Teemu O. Ihalainen; Soile Nymark; Marie-Paule Felder-Schmittbuhl
TAGS: bioluminescence, body tissue, circadian rhythms, mice, sclera, rhythm, pectoral compartment nerve block type 1, picture exchange communication system, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):62. https://doi.org/10.1167/iovs.66.6.62

Includes: Supplemental Content

Cornea June 2025

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

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Yue Li; Boyu Yang; Qi Chen; Yuchen Zhou; Wen Hu; Xiaojia Huang; Guangyi Huang; Ningning Tang; Fen Tang; Hui Huang; Qianqian Lan; Wenjing He; Fan Xu; Yiming Ye; Li Jiang
TAGS: alkalies, burns, cornea, corneal neovascularization, macrophages, necroptosis, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):54. https://doi.org/10.1167/iovs.66.6.54

Includes: Supplemental Content

Cornea June 2025

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

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Jingze Kan; Shiqi Song; Mengzhu Liu; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-3, cornea, fungal keratitis, infections, inflammation, keratitis, mice, pyroptosis, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):52. https://doi.org/10.1167/iovs.66.6.52

Cornea & External Disease June 2025

A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking

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Ana R. Arizcuren; Alejandra Consejo
TAGS: cornea, pixel
Trans. Vis. Sci. Tech.. 2025; 14(6):24. https://doi.org/10.1167/tvst.14.6.24

Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Cornea June 2025

M2a Macrophage-Dominant Microenvironment in Inflammation Attenuation and Wound Healing of Human Corneal Endothelial Cells

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Seung Hyeun Lee; Ahra Koh; Soo Jin Lee; Hun Lee; Kyoung Woo Kim
TAGS: cornea, exosomes, inflammation, macrophages, endothelial cells, endothelium, wound healing, wounds and injuries, anti-inflammatory agents, corneal endothelium
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):35. https://doi.org/10.1167/iovs.66.6.35

Includes: Supplemental Content

Review June 2025

Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review

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Siyin Liu; Lynn Kandakji; Aleksander Stupnicki; Dayyanah Sumodhee; Marcello T. Leucci; Scott Hau; Shafi Balal; Arthur Okonkwo; Ismail Moghul; Sandor P. Kanda; Bruce D. Allan; Dan M. Gore; Kirithika Muthusamy; Alison J. Hardcastle; Alice E. Davidson; Petra Liskova; Nikolas Pontikos
TAGS: artificial intelligence, cornea, corneal edema, corneal endothelium, datasets, diagnostic imaging, endothelium, eye, hereditary corneal dystrophy, systematic reviews
Trans. Vis. Sci. Tech.. 2025; 14(6):12. https://doi.org/10.1167/tvst.14.6.12

Includes: Supplemental Content

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Cornea June 2025

Cornea Nerves Can Identify Different Types of Parkinson's Disease

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Dongyu Li; Xinyu Zhang; Fan Yang; Xin Jin; Shumin Li; Haonan Yuan; Lifen Yao; Hong Zhang
TAGS: cornea, nervousness, neurons, parkinson disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):21. https://doi.org/10.1167/iovs.66.6.21

Cornea June 2025

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

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Yuki Oyama; Suguru Ito; Taichi Yuasa; Mizuki Ueda; Satoshi Chiba; Tatsuya Nakagawa; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi; Naoki Okumura
TAGS: endothelium, genes, hereditary corneal dystrophy, mice, trinucleotide repeat expansion, cornea, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):18. https://doi.org/10.1167/iovs.66.6.18

Includes: Supplemental Content

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Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis

Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

In Vivo Stability of Electronic Intraocular Lens Implant for Corneal Blindness

Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

M2a Macrophage-Dominant Microenvironment in Inflammation Attenuation and Wound Healing of Human Corneal Endothelial Cells

Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Cornea Nerves Can Identify Different Types of Parkinson's Disease

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

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