Eye Anatomy and Disorders

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Retina January 2025

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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Yan Wang; Dehuan Xu; Yuhang Zhao; Haiyu Zhu; Xiaoyu Xiu; Haiyan Jiang; Yimei Liu; Ge Shan; Shengzhou Wu
TAGS: mice, proteins, retina, serine, alzheimer's disease, regulation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):36. https://doi.org/10.1167/iovs.66.1.36

Includes: Supplemental Content

Retinal Cell Biology January 2025

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

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María M. Benedetto; Melisa Malcolm; Manuel G. Bruera; Laura G. Penazzi; Mario E. Guido; María A. Contín; Eduardo Garbarino-Pico
TAGS: retina, stress granules, arsenites, sodium, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):38. https://doi.org/10.1167/iovs.66.1.38

Includes: Supplemental Content

Cornea January 2025

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

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Yankai Wei; Mei Sun; Xinyu Zhang; Chengyuan Zhang; Chao Yang; Hong Nian; Bei Du; Ruihua Wei
TAGS: dry eye syndromes, mice, sjogren's syndrome, stat3 protein, th17 cells, langer-giedion syndrome, dendritic cells, t-lymphocytes, mice, inbred nod, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):35. https://doi.org/10.1167/iovs.66.1.35

Includes: Supplemental Content

Immunology and Microbiology January 2025

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

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Jiahui Yang; Jing Zhong; Zhenyuan Fu; Dalian He; Jing Zhang; Jin Yuan
TAGS: cornea, fungal keratitis, infections, macrophages, marenostrin, mice, phagocytosis, proteins, mycoses, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):33. https://doi.org/10.1167/iovs.66.1.33

Includes: Supplemental Content

Glaucoma January 2025

Relationship Between Intraocular Pressure and the True Rate of Functional and Structural Progression in the United Kingdom Glaucoma Treatment Study

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Giovanni Montesano; Alessandro Rabiolo; Giovanni Ometto; David P. Crabb; David F. Garway-Heath
TAGS: glaucoma, intraocular pressure, retinopathy of prematurity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):32. https://doi.org/10.1167/iovs.66.1.32

Includes: Supplemental Content

Letters to the Editor January 2025

An Alternative Mechanism for the Anti-Myopia Effectiveness of Diffusion Optics Technology (DOT) Lenses

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Timothy J. Gawne; Safal Khanal; Thomas T. Norton
TAGS: diffusion, lens (device), lens, crystalline, myopia, optics, technology
Trans. Vis. Sci. Tech.. 2025; 14(1):15. https://doi.org/10.1167/tvst.14.1.15

Retina January 2025

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

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Francesco Gelormini; Federico Ricardi; Guglielmo Parisi; Veronica Vallino; Beatrice Ghezzo; Claudia Cucciarelli; Paola Marolo; Maria Vittoria Cicinelli; Andrea Govetto; Mario R. Romano; Enrico Borrelli; Michele Reibaldi
TAGS: biological markers, epiretinal membrane, visual acuity, reading (activity), near visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):31. https://doi.org/10.1167/iovs.66.1.31

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Lens January 2025

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

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Wenjing Geng; Pengfei Li; Guowei Zhang; Renhao Zhong; Linhui Xu; Lihua Kang; Xi Liu; Miaomiao Wu; Min Ji; Huaijin Guan
TAGS: cataract, cortical cataract, paraptosis, lens, crystalline, lens epithelial cell, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):29. https://doi.org/10.1167/iovs.66.1.29

Includes: Supplemental Content

Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Low Vision Rehabilitation January 2025

Performance on Activities of Daily Living and User Experience When Using Artificial Intelligence by Individuals With Vision Impairment

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William Seiple; Hilde P. A. van der Aa; Fernanda Garcia-Piña; Izekiel Greco; Calvin Roberts; Ruth van Nispen
TAGS: activities of daily living, artificial intelligence, blindness, visual impairment, perception
Trans. Vis. Sci. Tech.. 2025; 14(1):3. https://doi.org/10.1167/tvst.14.1.3

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina January 2025

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

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Brandon D. Anderson; Brent A. Bell; Ying Song; Timothy T. Lee; Tan Wang; Joshua L. Dunaief
TAGS: age-related macular degeneration, nonexudative, atrophy, injections, iodates, sodium, mice, diagnostic imaging, retina
Trans. Vis. Sci. Tech.. 2025; 14(1):9. https://doi.org/10.1167/tvst.14.1.9

Includes: Supplemental Content

Public Health January 2025

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

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Po-Jen Lin; Alison G. Abraham; Pradeep Ramulu; Aleks Mihailovic; Anna Kucharska-Newton; Xinxing Guo
TAGS: community, eye, older adult, social determinants of health, visual impairment, physicians, aric trial, health, income
Trans. Vis. Sci. Tech.. 2025; 14(1):8. https://doi.org/10.1167/tvst.14.1.8

Includes: Supplemental Content

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Lens January 2025

Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens

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Nawal K. Khadka; Dieter Haemmerle; Paul H. Davis; Laxman Mainali
TAGS: lens (device), lens, crystalline, nuclear envelope, tissue membrane, cattle, lipids
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):27. https://doi.org/10.1167/iovs.66.1.27

Retina January 2025

Retinal Sensitivity in KCNV2 -Associated Retinopathy

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Thales A. C. de Guimaraes; Isabela M. C. de Guimaraes; Manickam Nick Muthiah; Angelos Kalitzeos; Michel Michaelides
TAGS: retinal diseases, visual acuity, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):26. https://doi.org/10.1167/iovs.66.1.26

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

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Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

Relationship Between Intraocular Pressure and the True Rate of Functional and Structural Progression in the United Kingdom Glaucoma Treatment Study

An Alternative Mechanism for the Anti-Myopia Effectiveness of Diffusion Optics Technology (DOT) Lenses

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Performance on Activities of Daily Living and User Experience When Using Artificial Intelligence by Individuals With Vision Impairment

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens

Retinal Sensitivity in KCNV2 -Associated Retinopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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