Glaucoma

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Glaucoma June 2025

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

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Xiaowei Yu; Hanxue Zhao; Yan Gao; Tao Zhou; Lin Deng; Miao Zhang; Hongyu Zhong; Feng Mei; Zhijun Li; Longyan Sun; Tianrui Zhang; Yan Shi; Zhigang Fan
TAGS: angle closure glaucoma, chinese (other dialects), chinese people, cohort studies, genetics, genotype, microphthalmos, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):9. https://doi.org/10.1167/iovs.66.6.9

Includes: Supplemental Content

Glaucoma June 2025

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

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Yumeng Zhang; Hanwen Huang; Huimin Zhong; Yang Zhang; Siqi He; Yanzhi Guo; Yiwei Wang; Ping Huang; Shouyue Huang; Yisheng Zhong
TAGS: aging, mice, older adult, signal transduction, retinal ganglion cells, western blotting, hypoxia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):8. https://doi.org/10.1167/iovs.66.6.8

Includes: Supplemental Content

Glaucoma June 2025

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

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Jianqi Chen; Xiaohua Zhuo; Yangjiani Li; Yingting Zhu; Zhidong Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Lei Lei
TAGS: body tissue, genes, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):7. https://doi.org/10.1167/iovs.66.6.7

Includes: Supplemental Content

Glaucoma June 2025

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
TAGS: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(6):7. https://doi.org/10.1167/tvst.14.6.7

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations

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Charis Y. N. Chiang; Xiaofei Wang; Stuart K. Gardiner; Martin Buist; Michaël J. A. Girard
TAGS: exophthalmos, eye, glaucoma, optic nerve, orbit, retinal ganglion cells, retinal nerve fiber layer, magnetic resonance imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):4. https://doi.org/10.1167/iovs.66.6.4

Includes: Supplemental Content

Glaucoma June 2025

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
TAGS: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2025; 14(6):6. https://doi.org/10.1167/tvst.14.6.6

Includes: Supplemental Content

Glaucoma June 2025

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

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Jie Wang; Karine D. Bojikian; Aiyin Chen; Ping Wei; Liang Liu; Yali Jia; David Huang
TAGS: angiogram, ganglia, optical coherence tomography, nerve fibers
Trans. Vis. Sci. Tech.. 2025; 14(6):5. https://doi.org/10.1167/tvst.14.6.5

Artificial Intelligence June 2025

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift

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Homa Rashidisabet; R. V. Paul Chan; Yannek I. Leiderman; Thasarat Sutabutr Vajaranant; Darvin Yi
TAGS: datasets, glaucoma
Trans. Vis. Sci. Tech.. 2025; 14(6):3. https://doi.org/10.1167/tvst.14.6.3

Includes: Supplemental Content

Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Glaucoma May 2025

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

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Royston K. Y. Tan; Tin A. Tun; Fabian A. Braeu; Shamira A. Perera; Michaël J. A. Girard
TAGS: iris, biomechanics, dilatation, pathologic, permeability
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):36. https://doi.org/10.1167/iovs.66.5.36

Glaucoma May 2025

Presbyopia Progression From the Age of 40 to 79 Years in Glaucoma Patients Treated With Prostaglandin F Receptor Agonists

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Masahiko Ayaki; Akiko Hanyuda; Kazuno Negishi
TAGS: agonists, glaucoma, presbyopia, prostaglandins f
Trans. Vis. Sci. Tech.. 2025; 14(5):25. https://doi.org/10.1167/tvst.14.5.25

Glaucoma May 2025

Usefulness of Measuring Corneal Stiffness in Predicting the Reduction of Intraocular Pressure With Microhook Ab Interno Trabeculotomy

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Kei Asaoka; Yuri Fujino; Honami Fukuyo; Hiroshi Murata; Shuichiro Aoki; Kaori Ishii; Yoshiaki Kiuchi; Ryo Asaoka
TAGS: cornea, intraocular pressure, trabeculotomy, postoperative care, glaucoma, preoperative care
Trans. Vis. Sci. Tech.. 2025; 14(5):19. https://doi.org/10.1167/tvst.14.5.19

Includes: Supplemental Content

Glaucoma May 2025

Metabolomic Profiling of Aqueous Humor From Glaucoma Patients Identifies Metabolites With Anti-Inflammatory and Neuroprotective Potential in Mice

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Monu Monu; Bhoj Kumar; Rahmat Asfiya; Nariman Nassiri; Vaama Patel; Shibandri Das; Sarah Syeda; Mamta Kanwar; Vivian Rajeswaren; Bret A. Hughes; Mark S. Juzych; Akhil Srivastava; Ashok Kumar; Pawan Kumar Singh
TAGS: agmatine, anti-inflammatory agents, aqueous humor, glaucoma, hypertension, metabolites, metabolomics, mice, open-angle glaucoma, thiamine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):28. https://doi.org/10.1167/iovs.66.5.28

Glaucoma May 2025

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

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Sowjanya Gowrisankaran; Ashkan Abbasi; Xubo Song; Joel S. Schuman; Gadi Wollstein; Bhavna J. Antony; Hiroshi Ishikawa
TAGS: glaucoma, optic disk, retinal nerve fiber layer, retinal vessels
Trans. Vis. Sci. Tech.. 2025; 14(5):13. https://doi.org/10.1167/tvst.14.5.13

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

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Emma Dow; Stephanie Kearney; Mhairi Day
TAGS: myopia, open-angle glaucoma, rhegmatogenous retinal detachment, visual impairment, decision support systems
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):82. https://doi.org/10.1167/iovs.66.4.82

Physiology and Pharmacology April 2025

Segmental Uveoscleral Outflow and its Relationship With Trabecular Outflow in Monkey Eyes

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Hoi-Lam Li; Su Yu; Shan Fan; Carol B. Toris; Haiyan Gong
TAGS: cercopithecidae, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):78. https://doi.org/10.1167/iovs.66.4.78

Includes: Supplemental Content

Physiology and Pharmacology April 2025

A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow

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Jennifer H. Tweedy; Mariia Dvoriashyna; Jessica R. Crawshaw; Darryl R. Overby; Rodolfo Repetto; Paul A. Roberts; Tamsin A. Spelman; Peter S. Stewart; Alexander J. E. Foss
TAGS: albumins, body tissue, chief complaint, fluid flow, intraocular pressure, sclera, unit of flow rate, sensitivity analysis, choroid, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):75. https://doi.org/10.1167/iovs.66.4.75

Includes: Supplemental Content

Glaucoma April 2025

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

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Julia V. Stingl; Cordula Braun; Sara Walter; Jasmin Rezapour; Felix M. Wagner; Lucy Shen; Alicja Strzalkowska; Irene Schmidtmann; Alexander K. Schuster; Esther M. Hoffmann
TAGS: bruch's basal membrane, child, optics, glaucoma, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):24. https://doi.org/10.1167/tvst.14.4.24

Includes: Supplemental Content

Glaucoma April 2025

Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma

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Davina A. Malek; Alberto Diniz-Filho; Erwin R. Boer; Felipe A. Medeiros
TAGS: blindness, glaucoma, reaction time, divided attention, visual fields
Trans. Vis. Sci. Tech.. 2025; 14(4):21. https://doi.org/10.1167/tvst.14.4.21

Includes: Supplemental Content

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Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

Presbyopia Progression From the Age of 40 to 79 Years in Glaucoma Patients Treated With Prostaglandin F Receptor Agonists

Usefulness of Measuring Corneal Stiffness in Predicting the Reduction of Intraocular Pressure With Microhook Ab Interno Trabeculotomy

Metabolomic Profiling of Aqueous Humor From Glaucoma Patients Identifies Metabolites With Anti-Inflammatory and Neuroprotective Potential in Mice

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

Segmental Uveoscleral Outflow and its Relationship With Trabecular Outflow in Monkey Eyes

A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma

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