Immunology and Microbiology

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Retinal Cell Biology January 2019

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

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Tina Storm; Thomas Burgoyne; Joshua L. Dunaief; Erik I. Christensen; Clare Futter; Rikke Nielsen
TAGS: ldl-receptor related protein 2, retinal degeneration, mice, ablation, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):322-330. doi: 10.1167/iovs.18-25667

Includes: Multimedia, Supplemental Content

Retina January 2019

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

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Wei Zhang; Yang Wang; Yichun Kong
TAGS: diabetes mellitus, hyperglycemia, inflammation, glucose, retinitis, rats, stem cell, mesenchymal, exosomes, hmgb1 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):294-303. doi: 10.1167/iovs.18-25617

Retinal Cell Biology January 2019

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

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Carsten Faber; Helene Bæk Juel; Benjamin Anderschou Holbech Jensen; Jan Pravsgaard Christensen; Jan Ulrik Prause; Allan Randrup Thomsen; Mogens Holst Nissen
TAGS: chemokines, genes, interferons, lymphocytic choriomeningitis virus, virus diseases, infection, choroid, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):192-201. doi: 10.1167/iovs.18-25721

Includes: Supplemental Content

Glaucoma January 2019

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
TAGS: stress response, stem cells, endoplasmic reticulum, trabecular meshwork, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):265-273. doi: 10.1167/iovs.18-25477

Includes: Supplemental Content

Cornea January 2019

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

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Xiangzhe Li; Boram Kang; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
TAGS: western blotting, secretagogues, immunoglobulin e, eye, immunoglobulin g, cytokine, cornea, carbon, prevention, mass or substance concentration per volume, normal saline, mucins, cervical lymph node group
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):255-264. doi: 10.1167/iovs.18-25964

Cornea January 2019

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

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Cameron K. Postnikoff; Andrew D. Pucker; John Laurent; Carrie Huisingh; Gerald McGwin; Jason J. Nichols
TAGS: small cell carcinoma of lung, contact lenses, lens, crystalline, lens (device), leukocytes, eye, sclera, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):226-233. doi: 10.1167/iovs.18-24664

Articles January 2019

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

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Joseph D. Bogaard; Jonathon B. Young; Asad Movahedan; Iris S. Kassem
TAGS: enoxaparin, child, animal model, triamcinolone, eye, fibrin, therapeutic intervention, oryctolagus cuniculus, postoperative care, anterior chamber of eye, inflammation, enzyme-linked immunosorbent assay, did not receive therapy or drug
Trans. Vis. Sci. Tech.. 2019; 8(1):5. doi: 10.1167/tvst.8.1.5

Immunology and Microbiology January 2019

Effect of Interferon alfa-2a Treatment on Adaptive and Innate Immune Systems in Patients With Behçet Disease Uveitis

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Ozgur Albayrak; Merih Oray; Fusun Can; Gunay Uludag Kirimli; Ahmet Gul; Ilknur Tugal-Tutkun; Sumru Onal
TAGS: behcet syndrome, uveitis, interferon alfa-2a, disease remission, antigens, cd25
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):52-63. doi: 10.1167/iovs.18-25548

Includes: Supplemental Content

Cornea January 2019

MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy

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Jianzhang Hu; XinYing Hu; Tong Kan
TAGS: neurons, autophagy, diabetes mellitus, neuropathy, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):16-25. doi: 10.1167/iovs.18-24968

Retinal Cell Biology December 2018

A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Müller Cell Disruption

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Weiyong Shen; So-Ra Lee; Michelle Yam; Ling Zhu; Ting Zhang; Victoria Pye; Ashish Easow Mathai; Keiichi Shibagaki; Jin-Zhong Zhang; Takeshi Matsugi; Mark C. Gillies
TAGS: endoglin, antibodies, neovascularization, pathologic, combined modality therapy, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6075-6088. doi: 10.1167/iovs.18-25628

Includes: Supplemental Content

Retina December 2018

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

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Helen T. Michael; Cari Graff-Cherry; Sung Chin; Corinne Rauck; Amelework D. Habtemichael; Patricia Bunda; Tunde Smith; Maria M. Campos; Kapil Bharti; Heinz Arnheiter; Glenn Merlino; Chi-Ping Day
TAGS: eye, pigment, pigmentation, ectopic gene expression, mitf protein, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6067-6073. doi: 10.1167/iovs.18-25186

Includes: Supplemental Content

Articles December 2018

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

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Peng Xu; Chifune Kai; Satoshi Kawasaki; Yuki Kobayashi; Kouji Yamamoto; Motokazu Tsujikawa; Ryuhei Hayashi; Kohji Nishida
TAGS: proteins, epcam gene, corneal epithelial cells, antibodies, epithelial cell adhesion molecule, genes, epithelium, cornea
Trans. Vis. Sci. Tech.. 2018; 7(6):30. doi: 10.1167/tvst.7.6.30

Immunology and Microbiology December 2018

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

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Aihua Tang; Armando R. Caballero; Mary E. Marquart; Michael A. Bierdeman; Richard J. O'Callaghan
TAGS: pseudomonas aeruginosa, mutation, catalysis, cornea, serine proteases, virulence factors, proteolytic enzymes, proteins, endopeptidases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5993-6002. doi: 10.1167/iovs.18-25834

Biochemistry and Molecular Biology December 2018

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

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Catherine J. Choi; Wensi Tao; Ravi Doddapaneni; Zenith Acosta-Torres; Nathan W. Blessing; Bradford W. Lee; Daniel Pelaez; Sara T. Wester
TAGS: prostaglandins, synthetic, bimatoprost
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5912-5923. doi: 10.1167/iovs.18-25134

Cornea December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

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Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura
TAGS: hyperglycemia, diabetes mellitus, type 1, body weight, alloxan, neurons, streptozocin, sural nerve, cornea, mice, nerve lesions
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5868-5875. doi: 10.1167/iovs.18-25693

Retinal Cell Biology December 2018

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

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Ryan D. Makin; Ivana Apicella; Yosuke Nagasaka; Hiroki Kaneko; Stephen D. Turner; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand
TAGS: phenotype, endothelial cells, endothelium
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5795-5802. doi: 10.1167/iovs.18-25215

Lens December 2018

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

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Laura Wernecke; Susanne Keckeis; Nadine Reichhart; Olaf Strauß; Daniel J. Salchow
TAGS: epithelium, cataract, child, pediatrics, rna, messenger, patient characteristics, cell transdifferentiation, lens epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5785-5794. doi: 10.1167/iovs.18-23789

Includes: Supplemental Content

Articles November 2018

Composition and Comparison of the Ocular Surface Microbiome in Infants and Older Children

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Kara M. Cavuoto; Santanu Banerjee; Darlene Miller; Anat Galor
TAGS: child, infant, eye, microbiome
Trans. Vis. Sci. Tech.. 2018; 7(6):16. doi: 10.1167/tvst.7.6.16

Includes: Supplemental Content

Retinal Cell Biology November 2018

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

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Shengxu Liu; Bingbing Xie; Xiaojing Song; Dandan Zheng; Liwen He; Guilan Li; Guanjie Gao; Fuhua Peng; Minzhong Yu; Jian Ge; Xiufeng Zhong
TAGS: retinal pigment cell, spheroids, cellular, organoids
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5659-5669. doi: 10.1167/iovs.17-23613

Includes: Supplemental Content

Cornea November 2018

The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c + Conventional Dendritic Cells Into the Inflamed Murine Cornea

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Maria J. Lopez; Yashar Seyed-Razavi; Arsia Jamali; Deshea L. Harris; Pedram Hamrah
TAGS: centers for disease control and prevention (u.s.), dendritic cells, cornea, mice, stromal cell-derived factor 1, cxcr4 receptors, chemokine receptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5671-5681. doi: 10.1167/iovs.18-25084

Includes: Supplemental Content

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Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

Effect of Interferon alfa-2a Treatment on Adaptive and Innate Immune Systems in Patients With Behçet Disease Uveitis

MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy

A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Müller Cell Disruption

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

Composition and Comparison of the Ocular Surface Microbiome in Infants and Older Children

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c + Conventional Dendritic Cells Into the Inflamed Murine Cornea

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Immunology and Microbiology

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