Immunology and Microbiology

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Immunology and Microbiology May 2022

Host Immune Response and Associated Clinical Features in a Primary Cytomegalovirus Eye Infection Model Using Anterior Chamber Inoculation

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Chien-Chia Su; Chia-Mao Gao; Fu-Ti Peng; Tzuu-Shuh Jou; I-Jong Wang
TAGS: anterior chamber of eye, cytokine, cytomegalovirus, cytomegalovirus infections, eye infections, ganciclovir, immune response, infections, lymph nodes, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):18. doi: https://doi.org/10.1167/iovs.63.5.18

Includes: Supplemental Content

Articles May 2022

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

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Wei Zhang; Alfrun Schönberg; Felix Bock; Claus Cursiefen
TAGS: cd40 ligand, cornea, eye, eyedrops, keratoplasty, rejection (psychology), telomeric repeat amplification protocol, thyroid hormone associated protein complex, allografting, transplantation
Trans. Vis. Sci. Tech.. 2022; 11(5):6. doi: https://doi.org/10.1167/tvst.11.5.6

Includes: Supplemental Content

Cornea May 2022

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

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Ren Liu; Jing Li; Yue Xu; Ziyan Chen; Huijing Ye; Jinhui Tang; Lai Wei; Lingyi Liang
TAGS: cytokine, epithelial cells, lipogenesis, meibomian gland, melatonin, mitogen-activated protein kinases, proteins, toll-like receptor 4
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):6. doi: https://doi.org/10.1167/iovs.63.5.6

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2022

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

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Fei Luo; Yu Tao; Mengyu Wang; Liuqing Yang; Ruifeng Su; Zhiqiang Pan; Xiaobo Tan
TAGS: 1-phosphatidylinositol 3-kinase, mice, phosphoinositide 3-kinase, eye inflammation, protein overexpression, allergic conjunctivitis, inflammatory response, proto-oncogene proteins c-akt, phenotype, akt signaling pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):4. doi: https://doi.org/10.1167/iovs.63.5.4

Retinal Cell Biology April 2022

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

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Ricardo Usategui-Martín; Kevin Puertas-Neyra; Nadia Galindo-Cabello; Leticia A. Hernández-Rodríguez; Fernando González-Pérez; José Carlos Rodríguez-Cabello; Rogelio González-Sarmiento; José Carlos Pastor; Ivan Fernandez-Bueno
TAGS: apoptosis, autophagy, genes, necroptosis, nerve degeneration, neuroprotective effect, oxidative stress, proteins, rna, messenger, secretome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):27. doi: https://doi.org/10.1167/iovs.63.4.27

Includes: Supplemental Content

Cornea April 2022

Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure

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Junji Hamuro; Kazuko Asada; Morio Ueno; Tomoko Yamashita; Atsushi Mukai; Tomoko Fujita; Eiko Ito; Nao Hiramoto; Munetoyo Toda; Chie Sotozono; Shigeru Kinoshita
TAGS: cd44 antigens, cells, corneal endothelium, gelatinase a, homing-associated cell adhesion molecule, micrornas, mitochondria, patient simulation, prostate health index, protected health information
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):22. doi: https://doi.org/10.1167/iovs.63.4.22

Includes: Supplemental Content

Cornea April 2022

Forkhead Domain Inhibitor-6 Suppresses Corneal Neovascularization and Subsequent Fibrosis After Alkali Burn in Rats

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Chunlin Lan; Guo Liu; Longxiang Huang; Xizhen Wang; Junkai Tan; Yun Wang; Ning Fan; Yihua Zhu; Man Yu; Xuyang Liu
TAGS: alkalies, burns, cornea, corneal neovascularization, fibrosis, inflammation, rats
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):14. doi: https://doi.org/10.1167/iovs.63.4.14

Lens April 2022

The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts

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Tiantian Qi; Ruihua Jing; Bo Ma; Conghui Hu; Chan Wen; Yongping Shao; Cheng Pei
TAGS: apoptosis, cataract, cataract, senile, hydrogen peroxide, ubiquitin-protein ligases, lens, crystalline, lens (device), proteins, lens epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):11. doi: https://doi.org/10.1167/iovs.63.4.11

Includes: Supplemental Content

Articles April 2022

Correlation of Complement Activation in Aqueous and Vitreous in Patients With Proliferative Diabetic Retinopathy

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Jesse M. Smith; Nikhil Mandava; Vanessa Tirado-Gonzalez; Rodrigo Garcia-Santisteban; Matthew D. Geiger; Jennifer L. Patnaik; Ashley Frazer-Abel; Anne M. Lynch; Naresh Mandava; V. Michael Holers; Brandie D. Wagner; Idaira Sanchez-Santos; Daniela Meizner; Hugo Quiroz-Mercado; Alan G. Palestine
TAGS: complement system proteins, diabetic retinopathy, proliferative diabetic retinopathy, vitreous body, complement activation
Trans. Vis. Sci. Tech.. 2022; 11(4):13. doi: https://doi.org/10.1167/tvst.11.4.13

Retinal Cell Biology April 2022

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

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Taku Wakabayashi; Hisamichi Naito; Tomohiro Iba; Kohji Nishida; Nobuyuki Takakura
TAGS: cell separation, choroid, endothelium, fluorescence, mice, retina, stem cells, electroconvulsive therapy, cd31 antigens, epidural cortical stimulation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):5. doi: https://doi.org/10.1167/iovs.63.4.5

Includes: Supplemental Content

Articles April 2022

Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines

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Ryan A. Gallo; Farhan Qureshi; Thomas A. Strong; Steven H. Lang; Kevin A. Pino; Galina Dvoriantchikova; Daniel Pelaez
TAGS: amphibia, anura, calcium, cell lines, mice, neuroglia, signal transduction, retina
Trans. Vis. Sci. Tech.. 2022; 11(4):4. doi: https://doi.org/10.1167/tvst.11.4.4

Includes: Multimedia, Supplemental Content

Articles April 2022

Intracameral Bacteriophage Injection as Postoperative Prophylaxis for Enterococcus faecalis –Induced Endophthalmitis After Cataract Surgery in Rabbits

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Tatsuma Kishimoto; Waka Ishida; Isana Nakajima; Takako Ujihara; Takashi Suzuki; Jumpei Uchiyama; Shigenobu Matsuzaki; Ken Fukuda
TAGS: bacteriophages, cataract surgery, endophthalmitis, injections, oryctolagus cuniculus, postoperative care, prevention, eye, enterococcus faecalis
Trans. Vis. Sci. Tech.. 2022; 11(4):2. doi: https://doi.org/10.1167/tvst.11.4.2

Immunology and Microbiology March 2022

Antimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis

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Victor Llorenç; Yukiko Nakamura; Christina Metea; Lisa Karstens; Blanca Molins; Phoebe Lin
TAGS: antimetabolites, autoimmunity, intestines, mice, microbiome, uveitis, water, immunization, retina, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):30. doi: https://doi.org/10.1167/iovs.63.3.30

Includes: Supplemental Content

Articles March 2022

Topical Administration of 0.3% Tofacitinib Suppresses M1 Macrophage Polarization and Allograft Corneal Rejection by Blocking STAT1 Activation in the Rat Cornea

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Jianfeng Yu; Pengfei Li; Zhuang Li; Yingqi Li; Jiawei Luo; Wenru Su; Dan Liang
TAGS: cornea, macrophages, tofacitinib, allografting, stat1 gene, administration, topical, keratoplasty, rejection (psychology)
Trans. Vis. Sci. Tech.. 2022; 11(3):34. doi: https://doi.org/10.1167/tvst.11.3.34

Cornea March 2022

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

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Peng Zhang; Lei Tian; Jiayu Bao; Shang Li; Ao Li; Ya Wen; Jingyi Wang; Ying Jie
TAGS: isotretinoin, meibomian gland, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):29. doi: https://doi.org/10.1167/iovs.63.3.29

Editorial March 2022

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2022; 11(3):25. doi: https://doi.org/10.1167/tvst.11.3.25

Editorial March 2022

Reviewers

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TAGS: acetylcholine, achondroplasia, burns, calculi, christianity, cluster headache, esters, glycogen storage disease type iv, ilex, laparoscopic uterosacral nerve ablation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):22. doi: https://doi.org/10.1167/iovs.63.3.22

Immunology and Microbiology March 2022

Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations

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Julian Wolf; Stefaniya Boneva; Dennis-Dominik Rosmus; Hansjürgen Agostini; Günther Schlunck; Peter Wieghofer; Anja Schlecht; Clemens Lange
TAGS: genes, microglia, monocytes, sequence analysis, rna, transcription, genetic, vitreous body, cell separation, body tissue, fluorescence, rna
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):9. doi: https://doi.org/10.1167/iovs.63.3.9

Includes: Supplemental Content

Articles March 2022

The Impact of Image Quality and Trachomatous Inflammation on Using Photography for Trachoma Prevalence Surveys

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Michelle Odonkor; Fahd Naufal; Harran Mkocha; Nicodemus Funga; Beatriz Muñoz; Sheila K. West
TAGS: image quality, inflammation, photography, surveys, trachoma, mismatch, eye, prevalence
Trans. Vis. Sci. Tech.. 2022; 11(3):11. doi: https://doi.org/10.1167/tvst.11.3.11

Immunology and Microbiology March 2022

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

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Andrew R. Griswold; Hsin-Che Huang; Daniel A. Bachovchin
TAGS: cornea, corneal epithelial cells, cytokine, inflammasomes, pyroptosis, value-based purchasing
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):2. doi: https://doi.org/10.1167/iovs.63.3.2

Includes: Supplemental Content

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Host Immune Response and Associated Clinical Features in a Primary Cytomegalovirus Eye Infection Model Using Anterior Chamber Inoculation

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure

Forkhead Domain Inhibitor-6 Suppresses Corneal Neovascularization and Subsequent Fibrosis After Alkali Burn in Rats

The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts

Correlation of Complement Activation in Aqueous and Vitreous in Patients With Proliferative Diabetic Retinopathy

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines

Intracameral Bacteriophage Injection as Postoperative Prophylaxis for Enterococcus faecalis –Induced Endophthalmitis After Cataract Surgery in Rabbits

Antimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis

Topical Administration of 0.3% Tofacitinib Suppresses M1 Macrophage Polarization and Allograft Corneal Rejection by Blocking STAT1 Activation in the Rat Cornea

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Reviewers

Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations

The Impact of Image Quality and Trachomatous Inflammation on Using Photography for Trachoma Prevalence Surveys

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

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