Immunology and Microbiology

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Retina July 2021

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

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Ahmed M. Abu El-Asrar; Mohd Imtiaz Nawaz; Ajmal Ahmad; Mohammad Mairaj Siddiquei; Eef Allegaert; Priscilla W. Gikandi; Gert De Hertogh; Ghislain Opdenakker
TAGS: angiogenesis, biological markers, diabetes mellitus, endothelial cells, enzyme-linked immunosorbent assay, inflammation, proliferative diabetic retinopathy, rats, retina, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):32. doi: https://doi.org/10.1167/iovs.62.9.32

Retina July 2021

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

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Han Han; Xiao Zhao; Mengyu Liao; Yinting Song; Caiyun You; Xue Dong; Xueli Yang; Xiaohong Wang; Bo Huang; Mei Du; Hua Yan
TAGS: epithelial to mesenchymal transition, eye, factor x, fibrosis, mice, ocular trauma, oryctolagus cuniculus, receptor, par-1, retinal pigment cell, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):29. doi: https://doi.org/10.1167/iovs.62.9.29

Includes: Supplemental Content

Retinal Cell Biology July 2021

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

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Xiaoling Shi; Nuo Dong; Qi Qiu; Shanhua Li; Jiaxing Zhang
TAGS: hypoxia, wounds and injuries, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):25. doi: https://doi.org/10.1167/iovs.62.9.25

Immunology and Microbiology July 2021

Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis

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Roos A. W. Wennink; Joke H. de Boer; Sanne Hiddingh; Anne-Mieke J. W. Haasnoot; Viera Kalinina Ayuso; Talitha de Hoop; Jessica van Setten; Eric Spierings; Jonas J. W. Kuiper
TAGS: alleles, human leukocyte antigens, uveitis, hla-dqb1, arthritis, juvenile rheumatoid, hla-drb1 gene, child, sequence analysis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):19. doi: https://doi.org/10.1167/iovs.62.9.19

Includes: Supplemental Content

Cornea July 2021

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease

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Safal Khanal; Yuqiang Bai; William Ngo; Kelly K. Nichols; Landon Wilson; Stephen Barnes; Jason J. Nichols
TAGS: biological markers, dry eye syndromes, fatty acids, meibomian gland dysfunction, tear film finding, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):13. doi: https://doi.org/10.1167/iovs.62.9.13

Cornea July 2021

The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis

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Ranran Zhang; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Xue Tian; Jiao Yin; Guiqiu Zhao
TAGS: aspergillus fumigatus, fungal keratitis, keratitis, proteins, immunity, natural, mice, rna, messenger, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):12. doi: https://doi.org/10.1167/iovs.62.9.12

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2021

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

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Bo Young Chun; Jong-Heon Kim; Youn-Kwan Jung; Yoon Seok Choi; Gunwoo Kim; Tomoko Yonezawa; Kyoungho Suk
TAGS: astrocytes, autoimmunity, mice, optic nerve, optic neuritis, plasma
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):8. doi: https://doi.org/10.1167/iovs.62.9.8

Includes: Supplemental Content

Immunology and Microbiology July 2021

Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury

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Haihan Jiao; Jason J. Ivanusic; Paul G. McMenamin; Holly R. Chinnery
TAGS: cornea, trpv1 receptor, wounds and injuries, neurons
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):6. doi: https://doi.org/10.1167/iovs.62.9.6

Includes: Supplemental Content

Cornea July 2021

The Role of Elastase in Corneal Epithelial Barrier Dysfunction Caused by Pseudomonas aeruginosa Exoproteins

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Ye Li; YingWei Wang; ChunWei Li; DePeng Zhao; QinYuan Hu; Min Zhou; Miao Du; Jian Li; PengXia Wan
TAGS: cornea, elastases, epithelium, pancreatic elastase, chronic exertional compartment syndrome, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):7. doi: https://doi.org/10.1167/iovs.62.9.7

Includes: Supplemental Content

Editorial July 2021

Reviewers

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TAGS: acetylcholine, achondroplasia, barrett's esophagus, calculi, christianity, crutches, esters, glycogen storage disease type iv, ilex, laparoscopic uterosacral nerve ablation
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):3. doi: https://doi.org/10.1167/iovs.62.9.3

Physiology and Pharmacology June 2021

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

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John T. Demirs; Junzheng Yang; Maura A. Crowley; Michael Twarog; Omar Delgado; Yubin Qiu; Stephen Poor; Dennis S. Rice; Thaddeus P. Dryja; Karen Anderson; Sha-Mei Liao
TAGS: complement system proteins, eye, rna, messenger, age-related macular degeneration, choroid, neural retina, donors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):26. doi: https://doi.org/10.1167/iovs.62.7.26

Includes: Supplemental Content

Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. doi: https://doi.org/10.1167/iovs.62.7.21

Visual Neuroscience June 2021

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi
TAGS: actins, rats, visual acuity, visual cortex, mitochondria, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):20. doi: https://doi.org/10.1167/iovs.62.7.20

Includes: Supplemental Content

Articles June 2021

Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study

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Zhenyu Wei; Kai Cao; Leying Wang; Christophe Baudouin; Antoine Labbé; Qingfeng Liang
TAGS: acanthamoeba keratitis, cornea, cysts, keratitis, acanthamoeba
Trans. Vis. Sci. Tech.. 2021; 10(7):10. doi: https://doi.org/10.1167/tvst.10.7.10

Includes: Supplemental Content

Retina June 2021

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration

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Kai Yuan Tey; Qiu Ying Wong; Yee Shan Dan; Andrew S. H. Tsai; Daniel S. W. Ting; Marcus Ang; Gemmy Chiu Ming Cheung; Shu Yen Lee; Tien Yin Wong; Quan V. Hoang; Chee Wai Wong
TAGS: eye, myopic macular degeneration, staphyloma, vitreous detachment, traction, medication therapy management, macular disorders, prevalence
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):7. doi: https://doi.org/10.1167/iovs.62.7.7

Retinal Cell Biology June 2021

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice, stress, ischemia, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):5. doi: https://doi.org/10.1167/iovs.62.7.5

Cornea June 2021

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami
TAGS: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology), transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):3. doi: https://doi.org/10.1167/iovs.62.7.3

Includes: Supplemental Content

Methods May 2021

Establishment and Characterization of a Novel Human Ocular Adnexal Sebaceous Carcinoma Cell Line

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Andrew J. Rong; Ryan A. Gallo; Michelle G. Zhang; Ravi Doddapaneni; Anthony J. Griswold; John Y. Lee; Stefan Kurtenbach; Sander R. Dubovy; David T. Tse; Daniel Pelaez
TAGS: cell lines, neoplasms, sebaceous adenocarcinoma, drug screening
Trans. Vis. Sci. Tech.. 2021; 10(6):34. doi: https://doi.org/10.1167/tvst.10.6.34

Includes: Supplemental Content

Cornea May 2021

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis

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Guoqiang Zhu; Leyu Lyu; Hua Yang; Jieun Lee; Jintao Sun; Jie Zhang; Shasha Xue; Haijing Yan; Limei Wang; Xiaomeng Chen; Chengye Che
TAGS: clec7a gene, keratitis, mice, polymerase chain reaction, aspergillus fumigatus, inflammatory response, cornea, western blotting, infections, protein overexpression
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):28. doi: https://doi.org/10.1167/iovs.62.6.28

Cornea May 2021

Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response

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Yunan Zhu; Xudong Peng; Yingxue Zhang; Jing Lin; Guiqiu Zhao
TAGS: fungal keratitis, inflammatory response, keratitis, mice, thymic stromal lymphopoietin, dimethyl sulfoxide, aspergillus fumigatus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):26. doi: https://doi.org/10.1167/iovs.62.6.26

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CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease

The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury

The Role of Elastase in Corneal Epithelial Barrier Dysfunction Caused by Pseudomonas aeruginosa Exoproteins

Reviewers

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

Establishment and Characterization of a Novel Human Ocular Adnexal Sebaceous Carcinoma Cell Line

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis

Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response

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