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Lens June 2025

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
TAGS: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(6):26. https://doi.org/10.1167/tvst.14.6.26

Lens June 2025

Light Influences Time-of-Day Differences in the Expression of Clock Genes and Redox Genes Involved in Glutathione Homeostasis in the Lens

PDF

Bo Li; Haruna Suzuki-Kerr; Christopher J. J. Lim; Renita M. Martis; Fenger Ou Yang; Erl Carlos; Paul J. Donaldson; Raewyn C. Poulsen; Julie C. Lim
TAGS: clock gene, genes, lens (device), lens, crystalline, glutathione, oxidation-reduction, regulation, homeostasis, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):24. https://doi.org/10.1167/iovs.66.6.24

Includes: Supplemental Content

Special Issue June 2025

Childhood Myopia Part I: Contemporary Treatment Options

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Safal Khanal; Erin S. Tomiyama; Síofra C. Harrington
TAGS: child, lens (device), lens, crystalline, myopia, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(7):6. https://doi.org/10.1167/iovs.66.7.6

Includes: Supplemental Content

Special Issue June 2025

How Have Animal Models Increased our Understanding of Human Myopia?

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Mark A. Bullimore
TAGS: animal model, myopia, lens (device), lens, crystalline, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(7):2. https://doi.org/10.1167/iovs.66.7.2

Cornea & External Disease June 2025

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

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Anthony Ain; Sylvain Poinard; Thierry Lepine; Oliver Dorado-Cortez; Sébastien Urbaniak; Jean-Marie Papillon; Philippe Gain; Gilles Thuret
TAGS: diagnostic imaging, lighting, slit lamps, light
Trans. Vis. Sci. Tech.. 2025; 14(6):11. https://doi.org/10.1167/tvst.14.6.11

Lens May 2025

PERK Regulates Epithelial–Mesenchymal Transition Through Autophagy and Lipid Metabolism in Lens Epithelial Cells

PDF

Xiaoran Wang; Baoxin Chen; Jieping Chen; Mi Huang; Shan Huang
TAGS: autophagy, endoplasmic reticulum stress, epithelial to mesenchymal transition, epithelium, fibrosis, lens (device), lens epithelial cell, lens, crystalline, fat metabolism, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):35. https://doi.org/10.1167/iovs.66.5.35

Includes: Supplemental Content

Lens May 2025

Identification of Age- and Cataract-Related Changes in High-Density Lens Protein Aggregates

PDF

Zhen Wang; Michael G. Friedrich; Roger J. W. Truscott; Kevin L. Schey
TAGS: cataract, crystallins, lens (device), lens, crystalline, proteins, peptides
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):34. https://doi.org/10.1167/iovs.66.5.34

Includes: Supplemental Content

Lens May 2025

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

PDF

Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan
TAGS: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna, thrombospondin 1, western blotting, protein overexpression, polymerase chain reaction, cataract surgery
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):20. https://doi.org/10.1167/iovs.66.5.20

Includes: Supplemental Content

Lens May 2025

Cholesterol and Q147E Deamidation Modulates αA-Crystallin Membrane Binding Elucidating Protective Role of Lens Membrane Composition Changes With Aging

PDF

Preston Hazen; Nawal K. Khadka; Laxman Mainali
TAGS: crystallins, lens (device), lens, crystalline, tissue membrane, cholesterol, aging, lipids
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):8. https://doi.org/10.1167/iovs.66.5.8

Clinical and Epidemiologic Research May 2025

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

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Maria K. Walker; David A. Berntsen; Matt L. Robich; Rachel L. Fenton; Anita Ticak; Justina R. Assaad; Hope M. Queener; Stephanie J. Chiu; Sina Farsiu; Donald O. Mutti; Lisa A. Jones-Jordan; Jeffrey J. Walline; for the BLINK Study Group
TAGS: child, choroid, contact lenses, lens (device), lens, crystalline, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):5. https://doi.org/10.1167/iovs.66.5.5

Includes: Supplemental Content

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

PDF

Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Artificial Intelligence May 2025

PhacoTrainer: Automatic Artificial Intelligence-Generated Performance Ratings for Cataract Surgery

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Hsu-Hang Yeh; Simmi Sen; Jonathan C. Chou; Karen L. Christopher; Sophia Y. Wang
TAGS: cataract, cataract surgery, intelligence, surgeons, surgical procedures, operative, phacoemulsification, eye
Trans. Vis. Sci. Tech.. 2025; 14(5):2. https://doi.org/10.1167/tvst.14.5.2

Includes: Supplemental Content

Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Lens April 2025

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

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Matthieu Duot; Sarah Y. Coomson; Sanjaya K. Shrestha; M. V. Murali Krishna Nagulla; Yann Audic; Ruteja A. Barve; Hongzhan Huang; Carole Gautier-Courteille; Luc Paillard; Salil A. Lachke
TAGS: datasets, embryo, epithelium, genes, lens epithelium, meta-analysis, mice, lens (device), lens, crystalline, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):42. https://doi.org/10.1167/iovs.66.4.42

Includes: Supplemental Content

Lens April 2025

Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery

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Caili Hao; Emily Fan; Zongbo Wei; Kazi Rafsan Radeen; Neha Purohit; Kailin Li; Sharad Purohit; Xingjun Fan
TAGS: cataract, cataract surgery, chronic inflammation, cytokine, hypertension, surgical procedures, operative, aqueous humor, surgery specialty, donors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):12. https://doi.org/10.1167/iovs.66.4.12

Includes: Supplemental Content

Lens April 2025

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang
TAGS: cell nucleus, eye, lens (device), lens, crystalline, myopia, visual accommodation, adult, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):6. https://doi.org/10.1167/iovs.66.4.6

Includes: Supplemental Content

Refractive Intervention April 2025

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

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Hou-Ren Tsai; Jeng-Hung Wang; Cheng-Jen Chiu
TAGS: cornea, orthokeratology, prospective studies, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2025; 14(4):5. https://doi.org/10.1167/tvst.14.4.5

Includes: Supplemental Content

Lens April 2025

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

PDF

Yuti Liu; Jiazhen Yao; Mingxue Ren; Lingxia Ye; An-Peng Pan; Xu Xu
TAGS: cataract, fluorocarbons, prevalence, national health and nutrition examination survey, adult
Trans. Vis. Sci. Tech.. 2025; 14(4):1. https://doi.org/10.1167/tvst.14.4.1

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Contributed Talks III: The Berkeley Widefield Model Eye

Austin Roorda; Pavan Tiruveedhula; Gareth Dudley Hastings
TAGS: eye
Journal of Vision. 2025; 25(5):56. https://doi.org/10.1167/jov.25.5.56

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Geometric phase multifocal ophthalmic lenses for presbyopics

Sunil Kumar Chaubey; Brian Vohnsen
TAGS: eye, lens (device), lens, crystalline, posters
Journal of Vision. 2025; 25(5):50. https://doi.org/10.1167/jov.25.5.50

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Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

Light Influences Time-of-Day Differences in the Expression of Clock Genes and Redox Genes Involved in Glutathione Homeostasis in the Lens

Childhood Myopia Part I: Contemporary Treatment Options

How Have Animal Models Increased our Understanding of Human Myopia?

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

PERK Regulates Epithelial–Mesenchymal Transition Through Autophagy and Lipid Metabolism in Lens Epithelial Cells

Identification of Age- and Cataract-Related Changes in High-Density Lens Protein Aggregates

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

Cholesterol and Q147E Deamidation Modulates αA-Crystallin Membrane Binding Elucidating Protective Role of Lens Membrane Composition Changes With Aging

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

PhacoTrainer: Automatic Artificial Intelligence-Generated Performance Ratings for Cataract Surgery

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

Contributed Talks III: The Berkeley Widefield Model Eye

Poster Session: Geometric phase multifocal ophthalmic lenses for presbyopics

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