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Genetics July 2025

Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration

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Christine A. Curcio; Robert F. Mullins; Edwin M. Stone; Lukas Goerdt; Deepayan Kar; Liyan Gao; Gerald McGwin, Jr.; Cynthia Owsley
TAGS: age-related macular degeneration, aging, eye, genetics, retinal cone, rod photoreceptors, vision, digestive tract decontamination, alleles
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):50. https://doi.org/10.1167/iovs.66.9.50

Includes: Supplemental Content

Retina July 2025

Retinal Mid-Peripheral Capillary Free Zones Are Enlarged in Diabetic Patients With No Evidence of Clinical Retinopathy

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Edmund Arthur; Swetha Ravichandran; Andrew Rothstein; Keisha Brown; Ganesh B. Jonnadula; Charles F. Murchison; Maria B. Grant
TAGS: diabetes mellitus, blood capillaries, retinal diseases
Trans. Vis. Sci. Tech.. 2025; 14(7):10. https://doi.org/10.1167/tvst.14.7.10

Artificial Intelligence July 2025

Three-Dimensional Quantification of Macular OCT Alterations Improves the Diagnostic Performance of Artificial Intelligence Models

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Lukas Heine; Anna Vahldiek; Benja Vahldiek; Fabian Hörst; Constantin Seibold; Mael Lever; Laurenz Pauleikhoff; Nikolaos Bechrakis; Daniel Pauleikhoff; Jens Kleesiek
TAGS: age-related macular degeneration, artificial intelligence, cohort studies, datasets, masks, volume
Trans. Vis. Sci. Tech.. 2025; 14(7):8. https://doi.org/10.1167/tvst.14.7.8

Includes: Supplemental Content

Expression of Concern July 2025

Expression of Concern for: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo

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TAGS: apoptosis, glaucoma, glutamate, glutamates, neuroprotective effect, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):34. https://doi.org/10.1167/iovs.66.9.34

Retina July 2025

Early Photoreceptor Alterations After Retinal Detachment Repair

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Sandrine H. Sassen; Josua Sassen; Marlene Sassmannshausen; Lukas Goerdt; Yannick Liermann; Raffael G. Liegl; Philipp Herrmann; Robert P. Finger; Frank G. Holz; Sarah Thiele
TAGS: detached retina repairs, photoreceptors, postoperative care, rhegmatogenous retinal detachment, surgical procedures, operative, cohort studies, spectral domain-optical coherence tomography, macula lutea, personal integrity, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):32. https://doi.org/10.1167/iovs.66.9.32

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging July 2025

Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease

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Natasa Jeremic; Meltem Esengönül; Azin Zarghami; Maximilian Pawloff; Matthias Hasun; Markus Schreiner; Reinhard Windhager; Alexander Niessner; Andreas Pollreisz; Hrvoje Bogunovic; Ursula Schmidt-Erfurth
TAGS: coronary arteriosclerosis, oxygen diffusion, perfusion, comorbidity, artifacts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):27. https://doi.org/10.1167/iovs.66.9.27

Includes: Supplemental Content

Retina July 2025

Exosomal miRNA Profiling in Liquid Biopsy of Vitreous in Proliferative Diabetic Retinopathy

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Bin Yan; Jianing Qiu; Yan Yang; Jing Luo; Dan Liu; Lusi Zhang; Zhishang Meng; Huiling Li; Xiaojian Guo; Jun Zeng; Chun Ding; Manyun Xie; Kejun Long
TAGS: micrornas, vitreous body, proliferative diabetic retinopathy, liquid biopsy, exosomes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):24. https://doi.org/10.1167/iovs.66.9.24

Glaucoma July 2025

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

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Tingting Liu; Ya Xing Wang; Jost B. Jonas; Quan V. Hoang; Michaël J. A. Girard; Xiaofei Wang
TAGS: eye, gaze, myopia, optic disk, eye movement, sclera, adduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):21. https://doi.org/10.1167/iovs.66.9.21

Includes: Supplemental Content

Retina July 2025

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

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Mai Alhelaly; Ceren Soylu; Giulia Corradetti; Federico Corvi; Alireza Mahmoudi; Rouzbeh Abbasgholizadeh; Giovanni Bellisario; Ye He; Alberto Quarta; Muneeswar G. Nittala; Giovanni Staurenghi; SriniVas R. Sadda
TAGS: bruch's basal membrane, exudative age-related macular degeneration, eye, macular neovascularization, optical coherence tomography, injections, diagnostic imaging, visual acuity, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):19. https://doi.org/10.1167/iovs.66.9.19

Retinal Cell Biology July 2025

Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey

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Shoji Notomi; Guannan Wu; Takaharu Nagaoka; Nao Yotsumoto; Tomoaki Araki; Mitsuru Arima; Toshio Hisatomi; Koh-Hei Sonoda; Kazutoshi Sawada
TAGS: apoptosis, cercopithecidae, iodates, macaca fascicularis, macula lutea, macular degeneration, rod photoreceptors, sodium, young adult, histopathology tests
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):18. https://doi.org/10.1167/iovs.66.9.18

Includes: Supplemental Content

Retina July 2025

Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length

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Guitong Ye; Yuan Zhang; Shaofen Huang; Jinan Zhan; Ruiyu Luo; Rui Xie; Yuyao Ling; Ye Deng; Caibin Deng; Wei Liu; Zhiwei Huang; Chusheng Zhang; Junshu Wu; Zhidong Li; Yehong Zhuo
TAGS: cardiovascular imaging, choroid, cortical blindness, macaca, macaca fascicularis, myopia, eye, antidepressive agents, tricyclic, trichloroacetic acid, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):17. https://doi.org/10.1167/iovs.66.9.17

Includes: Supplemental Content

Retina July 2025

Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes

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Nicola Valsecchi; Maurizio Mete; Giulio Rapezzi; Matteo Elifani; Giulia Folgaria; Alessandro Finzi; Antonio Moramarco; Luigi Fontana
TAGS: epiretinal membrane, eye, heart failure, surgical procedures, operative, postoperative care
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):14. https://doi.org/10.1167/iovs.66.9.14

Article July 2025

Computational evidence for an inverse relationship between retinal and brain complexity

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Mitchell B. Slapik
TAGS: brain, datasets, retina
Journal of Vision. 2025; 25(8):9. https://doi.org/10.1167/jov.25.8.9

Includes: Supplemental Content

Genetics July 2025

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

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Kirk A. J. Stephenson; Tiffany Tse; Jiwon Hwang; Andrii Kavetskyi; Shanil R. Dhanji; Olubayo U. Kolawole; Cheryl Y. Gregory-Evans; Kaivon Pakzad-Vaezi; Zaid N. Mammo; Kevin Gregory-Evans; Myeong Jin Ju
TAGS: cardiovascular imaging, cortical blindness, eye, genotype, retinitis pigmentosa, myopia, cohort studies, pseudophakia, volume, choroid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):11. https://doi.org/10.1167/iovs.66.9.11

Includes: Supplemental Content

Retina July 2025

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units

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Mizuho Mitamura; Satoru Kase; Hiroaki Endo; Michiyuki Saito; Satoshi Katsuta; Susumu Ishida
TAGS: diabetes mellitus, diabetes mellitus, type 2, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):10. https://doi.org/10.1167/iovs.66.9.10

Retina July 2025

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris
TAGS: angiogenesis, methamphetamine, rats, self administration, retina, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):8. https://doi.org/10.1167/iovs.66.9.8

Immunology and Microbiology July 2025

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

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Xuexue Cui; Caijiao Yi; Jian Liu; Jinyan Qi; Wen Deng; Xiangling Yuan; Ruiqi Zhou; Mei Chen; Qiang Xiang; Heping Xu
TAGS: antibiotics, gastrointestinal microbiome, mice, retinal injuries, wounds and injuries, laser injuries, attenuation, lasers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):6. https://doi.org/10.1167/iovs.66.9.6

Includes: Supplemental Content

Visual Neuroscience July 2025

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

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Hong Zhou; Guimei Zhou; Qin Yang; Jiahao Niu; Runzhe Wang; Huilan Liu; Suwen Hou; Hongsheng Bi; Xuan Liao
TAGS: antagonists, caviidae, muscarinic acetylcholine receptor, myopia, retina, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):5. https://doi.org/10.1167/iovs.66.9.5

Genetics July 2025

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster
TAGS: phenotype, retinal diseases, electroretinography, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):3. https://doi.org/10.1167/iovs.66.9.3

Includes: Supplemental Content

Retina July 2025

Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment

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Fabian Yii; Ian J. C. MacCormick; Niall Strang; Miguel O. Bernabeu; Tom MacGillivray
TAGS: biological markers, refraction, retinal detachment, eye, medical history, uk biobank, sensitivity analysis, cox proportional hazards models, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):1. https://doi.org/10.1167/iovs.66.9.1

Includes: Supplemental Content

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Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration

Retinal Mid-Peripheral Capillary Free Zones Are Enlarged in Diabetic Patients With No Evidence of Clinical Retinopathy

Three-Dimensional Quantification of Macular OCT Alterations Improves the Diagnostic Performance of Artificial Intelligence Models

Expression of Concern for: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo

Early Photoreceptor Alterations After Retinal Detachment Repair

Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease

Exosomal miRNA Profiling in Liquid Biopsy of Vitreous in Proliferative Diabetic Retinopathy

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey

Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length

Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes

Computational evidence for an inverse relationship between retinal and brain complexity

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment

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